Evidence map›Paper›PMID 33436314›Full record

ReviewTrends in parasitology2021

Serological Approaches for Trypanosoma cruzi Strain Typing.

Virginia Balouz, Leonel Bracco, Alejandro D Ricci, Guadalupe Romer, Fernán Agüero, Carlos A Buscaglia

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Fulminant and fatalASM case reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  7. Genetic Diversity ofLife (Basel, Switzerland) · 2024
    Review
  8. Fifteen Years after the Definition ofLife (Basel, Switzerland) · 2023
    Review
  9. Article
  10. All Roads Lead to Cytosol:Frontiers in cellular and infection microbiology · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Virginia BalouzLaboratory of Molecular Biology of Protozoa, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina.
Leonel BraccoTrypanosomatics Laboratory, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina.
Alejandro D RicciTrypanosomatics Laboratory, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina.
Guadalupe RomerLaboratory of Molecular Biology of Protozoa, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina.
Fernán AgüeroTrypanosomatics Laboratory, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina. Electronic address: fernan@iib.unsam.edu.ar.
Carlos A BuscagliaLaboratory of Molecular Biology of Protozoa, Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), Universidad Nacional de General San Martín (UNSAM)-CONICET, Buenos Aires, Argentina. Electronic address: cbuscaglia@iib.unsam.edu.ar.

Funding

HIGH-THROUGHPUT EPITOPE DISCOVERY: USE OF NEXT-GENERATION PEPTIDE CHIPS FOR FAST IDENTIFICATION AND FINE MAPPING OF DIAGNOSTIC AND PROGNOSTIC MARKERS FOR CHAGAS DISEASER01AI123070 · NIAID · INSTITUTE/RESEARCH/BIOTECHNOLOGY FDN · PI AGUERO, FERNAN GONZALO · 2016 to 2020
$611k
NIAID NIH HHS R01 AI123070
6 · The paper itself

Abstract

Trypanosoma cruzi, the protozoan agent of Chagas' disease, displays a complex population structure made up of multiple strains showing a diverse ecoepidemiological distribution. Parasite genetic variability may be associated with disease outcome, hence stressing the need to develop methods for T. cruzi typing in vivo. Serological typing methods that exploit the presence of host antibodies raised against polymorphic parasite antigens emerge as an appealing approach to address this issue. These techniques are robust, simple, cost-effective, and are not curtailed by methodological/biological limitations intrinsic to available genotyping methods. Here, we critically assess the progress towards T. cruzi serotyping and discuss the opportunity provided by high-throughput immunomics to improve this field.

Indexed as

AnimalsChagas DiseaseHumansParasitologySerologic TestsSpecies SpecificityTrypanosoma cruzidiscrete typing unitsgenetic variabilityhigh-throughput immunomicsserotypingTrypanosoma cruzitrypomastigote small surface antigen

Identifiers

PMID33436314
PMCPMC8900812

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.