Evidence map›Paper›PMID 33436123›Full record

ArticleEpidemiology and infection2021

Impact of PD-1 gene polymorphism and its interaction with tea drinking on susceptibility to tuberculosis.

Jing Wang, Mian Wang, Zihao Li, Xinyin Wu, Xian Zhang, Abesig Julius, Hua Zhong, Xin Huang, Mengshi Chen, Hongzhuan Tan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jing WangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Mian WangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Zihao LiDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Xinyin WuDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Xian ZhangDepartment of Occupational and Environmental Hygiene, Xiangya School of Public Health, Central South University, Changsha, China.
Abesig JuliusDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.ORCID 0000-0002-0061-8244
Hua ZhongDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Xin HuangDepartment of Epidemiology and Health Statistics, Hunan Normal University, Changsha, China.
Mengshi ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.ORCID 0000-0002-9100-0967
Hongzhuan TanDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Hengzhong YiHunan Institute of Tuberculosis Prevention and Treatment, Changsha, China.
Central South University · CNHeilongjiang Center for Tuberculosis Control and Prevention · CNHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to explore the impact of polymorphism of PD-1 gene and its interaction with tea drinking on susceptibility to tuberculosis (TB). A total of 503 patients with TB and 494 controls were enrolled in this case-control study. Three single-nucleotide polymorphisms of PD-1 (rs7568402, rs2227982 and rs36084323) were genotyped and unconditional logistic regression analysis was used to identify the association between PD-1 polymorphism and TB, while marginal structural linear odds models were used to estimate the interactions. Genotypes GA (OR 1.434), AA (OR 1.891) and GA + AA (OR 1.493) at rs7568402 were more prevalent in the TB patients than in the controls (P < 0.05). The relative excess risk of interaction (RERI) between rs7568402 of PD-1 genes and tea drinking was -0.3856 (95% confidence interval -0.7920 to -0.0209, P < 0.05), which showed a negative interaction. However, the RERIs between tea drinking and both rs2227982 and rs36084323 of PD-1 genes were not statistically significant. Our data demonstrate that rs7568402 of PD-1 genes was associated with susceptibility to TB, and there was a significant negative interaction between rs7568402 and tea drinking. Therefore, preventive measures through promoting the consumption of tea should be emphasised in the high-risk populations.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideTeaCase-Control StudiesFemaleGenotypeHumansMaleProgrammed Cell Death 1 ReceptorTuberculosisPDCD1 protein, humanProgrammed Cell Death 1 ReceptorTeaGene–environment interactionPD-1RERItea drinkingtuberculosis

Identifiers

PMID33436123
PMCPMC8057366
OpenAlexW3120753212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.