Evidence map›Paper›PMID 33436100›Full record

ArticleMicrobiome2021

Group therapy on in utero colonization: seeking common truths and a way forward.

Rachel B Silverstein, Indira U Mysorekar

Open access · goldAbstract read
In one paragraph

Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  10. Prenatal exposure to Hurricane Maria is associated with an altered infant nasal microbiome.The journal of allergy and clinical immunology. Global · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel B SilversteinDepartment of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA.
Indira U MysorekarDepartment of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA. imysorekar@wustl.edu.ORCID 0000-0003-3917-8677
Washington University in St. Louis · US

Funding

Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)R01HD091218 · NICHD · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, MYSOREKAR, INDIRA U · 2017 to 2022
$4.1M
NICHD NIH HHS R01 HD091218
6 · The paper itself

Abstract

The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted after decades of disbelief that a broad understanding of human development, health, physiology, and disease requires understanding of the microbiome along with the genome and epigenome. We are learning daily of the interdependent relationships between microbiome/microbiota and immune responses, mood, cancer progression, response to therapies, aging, obesity, antibiotic usage, and overusage and much more. The next frontier in microbiome field is understanding when does this influence begin? Does the human microbiome initiate at the time of birth or are developing human fetuses already primed with microbes and their products in utero. In this commentary, we reflect on evidence gathered thus far on this question and identify the unknown common truths. We present a way forward to continue understanding our microbial colleagues and our interwoven fates.

Indexed as

ConsensusFemaleFetusHumansMicrobiotaUncertaintyUterusDeciduaExtravillous trophoblastsKitomeLow biomass microbial communitiesMicrobiomeMicrococcusPlacentaPregnancyRalstonia

Identifiers

PMID33436100
PMCPMC7805186
OpenAlexW3119108966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.