Evidence map›Paper›PMID 33436082›Full record

ArticleArthritis research & therapy2021

Photoacoustic and high-frequency ultrasound imaging of systemic sclerosis patients.

Khalid Daoudi, Brigit E Kersten, Cornelia H M van den Ende, Frank H J van den Hoogen, Madelon C Vonk, Chris L de Korte

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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  8. Novel therapies and innovation for systemic sclerosis skin ulceration.Best practice & research. Clinical rheumatology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Khalid DaoudiMedical UltraSound Imaging Center (MUSIC), Department of Radiology and Nuclear Medicine, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands.
Brigit E KerstenDepartment of Rheumatic Diseaes Radboud University Medical Center, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands. B.Kersten@radboudumc.nl.
Cornelia H M van den EndeMedical UltraSound Imaging Center (MUSIC), Department of Radiology and Nuclear Medicine, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands.
Frank H J van den HoogenMedical UltraSound Imaging Center (MUSIC), Department of Radiology and Nuclear Medicine, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands.
Madelon C VonkMedical UltraSound Imaging Center (MUSIC), Department of Radiology and Nuclear Medicine, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands. Madelon.Vonk@radboudumc.nl.ORCID 0000-0002-2266-9907
Chris L de KorteDepartment of Rheumatic Diseaes Radboud University Medical Center, Sint Maartenskliniek Post 766, PO box 9101, 6500 HB, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLSint Maartenskliniek · NLSint Maartenskliniek · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSystemic sclerosis starts with an early phase characterized by Raynaud's phenomenon, puffy fingers/hands, autoantibodies, and a scleroderma nailfold microscopic pattern. Alterations in the nailfold microscopic pattern are not evident in all early SSc patients. Photoacoustics (PA) and high-frequency ultrasound (HFUS) could fulfill this need. The former can measure oxygen saturation while the latter can measure skin thickening. We hypothesize that photoacoustics and high-frequency ultrasound can distinguish (early) SSc patients from individuals with primary Raynaud's phenomenon (PRP) by measuring oxygenation of the fingertip and skin thickening.

methodsWe compared measurements of oxygenation and skin thickness of the third finger between (early) SSc patients and PRP individuals and healthy controls. The spearman rank correlation was used to analyze an association between capillary density and oxygen saturation of the fingers.

resultsThirty-one adult subjects participated in this study: twelve patients with SSc, 5 patients with early SSc, 5 volunteers with PR, and 9 healthy controls. We found a significant difference in oxygen saturation between (early) SSc patients (80.8% ± 8.1 and 77.9% ± 10.5) and individuals with PRP (93.9% ± 1.1). Measurements of skin thickening showed a significant difference in (early) SSc patients compared to individuals with PRP (0.48 ± 0.06 mm and 0.51 ± 0.16 mm vs. 0.27 ± 0.01 mm). There was no significant difference between healthy and PRP individuals in oxygenation or skin thickening.

conclusionPhotoacoustic and high-frequency ultrasound could help to distinguish between (early) SSc, PRP, and healthy individuals in both oxygenation and skin thickening.

Indexed as

Raynaud DiseaseScleroderma, SystemicAdultCapillariesFingersHumansMicroscopic AngioscopyUltrasonographyEarly diagnosisHigh-frequency ultrasoundPhotoacousticSkin thickeningSystemic sclerosis

Identifiers

PMID33436082
PMCPMC7802269
OpenAlexW3119836102

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.