Evidence map›Paper›PMID 33436061›Full record

ReviewCell & bioscience2021

Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications.

Leila Gholami, Vajihe Taghdiri Nooshabadi, Shiva Shahabi, Marzieh Jazayeri, Rana Tarzemany, Zohreh Afsartala, Khatereh Khorsandi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Review
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  5. Unveiling the dual role ofPlant signaling & behavior · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
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  14. Review
  15. Review
  16. Delivery of Growth Factors to Enhance Bone Repair.Bioengineering (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leila GholamiDepartment of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Vajihe Taghdiri NooshabadiDepartment of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Science, Semnan, Iran.
Shiva ShahabiStudent Research Committee, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Marzieh JazayeriStudent Research Committee, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Rana TarzemanyDepartment of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada.
Zohreh AfsartalaBrain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran.
Khatereh KhorsandiDepartment of Photodynamic, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran. khorsandi.kh@ut.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs' EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.

Indexed as

Bone regenerationExtracellular vesiclesMesenchymal stem cellsPeriodontal regeneration

Identifiers

PMID33436061
PMCPMC7802187

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.