Evidence map›Paper›PMID 33435953›Full record

ArticleCancer cell international2021

LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.

Hao Xu, Xin Miao, Xin Li, Haofei Chen, Bo Zhang, Wence Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hao XuThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Xin MiaoState Key Laboratory of Veterinary Etiological Biology & OIE/National Foot and Mouth Disease Reference Laboratory & Key Laboratory of Animal Virology of the Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xin LiThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Haofei ChenThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Bo ZhangThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Wence ZhouThe Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China. zhouwc129@163.com.ORCID http://orcid.org/0000-0002-0529-7777

Funding

Key Research and Development Program of Gansu No. 17YF1FA128Lanzhou Science and Technology Bureau Innovation and Entrepreneurship Talent Program No. 2017-RC-37
6 · The paper itself

Abstract

backgroundIt has been reported that the lncRNA SNHG16 has significantly increased expression in pancreatic adenocarcinoma (PC). However, the functions and mechanisms of SNHG16 are not clear. The aim of this study was to explore the effects of SNHG16 on PC.

methodsqRT-PCR analysis was applied to detect the expression levels of SNHG16, miR-302b-3p and SLC2A4 in PC tissues and cells. CCK8 and EdU assays were used to evaluate the proliferation of PC cells. Transwell assays were used to assess PC cell migration and invasion. Apoptosis was evaluated by flow cytometry, and the expression of apoptosis-related proteins (including Bax, Bcl-2, cleaved caspase-3 and cleaved caspase-9) was tested by western blotting. The interactions between miR-302b-3p and SNHG16 or miR-302b-3p and the 3'UTR of SLC2A4 mRNA were clarified by a dual luciferase reporter assay and RNA immunoprecipitation.

resultsSNHG16 expression was significantly elevated in PC tissues and cell lines and was associated with poor prognosis of PC patients. Knockdown of SNHG16 reduced PC cell proliferation, migration and invasion. SNHG16 acted as a sponge to regulate miR-302b-3p expression in PC cells. In addition, miR-302b-3p targeted SLC2A4 directly.

conclusionsSNHG16 promoted the progression of PC via the miR-302b-3p/SLC2A4 axis and was expected to be a potential target for the early diagnosis and treatment of PC.

Indexed as

miR-302b-3pPancreatic adenocarcinomaSLC2A4SNHG16

Identifiers

PMID33435953
PMCPMC7805184

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