Observational studyBMC pulmonary medicine2021
Cardiorespiratory coupling is associated with exercise capacity in patients with chronic obstructive pulmonary disease.
Observational study in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Monitoring of respiration and cardiorespiratory interactions from multichannel seismocardiography signals.Physical and engineering sciences in medicine · 2026Article
- Cardioneuroablation Acutely Affects the Amplitude and Efficiency of Respiratory Heart Rate Variability.Journal of clinical medicine · 2026Article
- Two-week heart rate variability measurements and lung health: a cross-sectional analysis in the ARIC study.Respiratory medicine · 2025Article
- A study on the immediate effects of enhanced external counterpulsation on physiological coupling.Frontiers in neuroscience · 2023Article
- Changes in Forcecardiography Heartbeat Morphology Induced by Cardio-Respiratory Interactions.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe interaction between the pulmonary function and cardiovascular mechanics is a crucial issue, particularly when treating patients with chronic obstructive pulmonary disease (COPD). Synchrogram index is a new parameter that can quantify this interaction and has the potential to apply in COPD patients. Our objective in this study was to characterize cardiorespiratory interactions in terms of cardiorespiratory coupling (CRC) using the synchrogram index of the heart rate and respiratory flow signals in patients with chronic obstructive pulmonary disease.
methodsThis is a cross-sectional and preliminary data from a prospective study, which examines 55 COPD patients. K-means clustering analysis was applied to cluster COPD patients based on the synchrogram index. Linear regression and multivariable regression analysis were used to determine the correlation between the synchrogram index and the exercise capacity assessed by a six-minute walking test (6MWT).
resultsThe 55 COPD patients were separated into a synchronized group (median 0.89 (0.64-0.97), n = 43) and a desynchronized group (median 0.23 (0.02-0.51), n = 12) based on K-means clustering analysis. Synchrogram index was correlated significantly with six minutes walking distance (r = 0.42, p = 0.001) and distance saturation product (r = 0.41, p = 0.001) assessed by 6MWT, and still was an independent variable by multivariable regression analysis.
conclusionThis is the first result studying the heart-lung interaction in terms of cardiorespiratory coupling in COPD patients by the synchrogram index, and COPD patients are clustered into synchronized and desynchronized groups. Cardiorespiratory coupling is associated with exercise capacity in patients with COPD.
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