Evidence map›Paper›PMID 33435910›Full record

ArticleBMC neurology2021

Dorsolateral medullary infarction registry: a study protocol for a prospective, multicentric registry.

Jing Wang, Pei Liu, Zhongzhong Liu, Ye Tian, Guilian Zhang, Jun Guo, Li Li, Zhiqin Liu, Zucheng Han, Wenjuan Lin and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Jing WangDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Pei LiuDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Zhongzhong LiuDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Ye TianDepartment of Neurology, Third Hospital of Xi'an, the Affiliated Hospital of Northwest University, 710018, Xi'an, Shaanxi Province, China.
Guilian ZhangDepartment of Neurology, the Second Affiliated Hospital of Xi'an Jiaotong University, 710004, Xi'an, Shaanxi Province, China.
Jun GuoDepartment of Neurology, Tangdu Hospital, Air Force Military Medical University, 710038, Xi'an, Shaanxi Province, China.
Li LiDepartment of Neurology, Xijing Hospital, Air Force Military Medical University, 710032, Xi'an, Shaanxi Province, China.
Zhiqin LiuDepartment of Neurology, Xi'an Central Hospital, Xi'an Jiaotong University School of Medicine, 710003, Xi'an, Shaanxi Province, China.
Zucheng HanEncephalopathy Hospital, Shanxi Provincial Hospital of Traditional Chinese Medicine, 710077, Xi'an, Shaanxi Province, China.
Wenjuan LinCollege of Life Sciences, Northwest University, 710069, Xi'an, Shaanxi Province, China.
Xuemei LinDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Qingli LuDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Yan LiuDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Qiaoqiao ChangDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China.
Songdi WuDepartment of Neurology, First Hospital of Xi'an, 710002, Xi'an, Shaanxi Province, China. wusongdi@gmail.com.
First Hospital of Xi'an · CNNorthwest University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNXi'an Jiaotong University · CN

Funding

Science and Technology Plan Major Project of Xi'an city 20YXYJ0008(1)
6 · The paper itself

Abstract

backgroundDorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction.

methodsThis study will involve consecutive data from all medical records of patients within 7 days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2 years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period. DISCUSSION: This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea.

trial registrationThe registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.

Indexed as

RegistriesAdultCerebral InfarctionCorneal DiseasesFemaleHumansMaleMedulla OblongataMiddle AgedCorneal innervationDorsolateral medullary infarctionNeurotrophic keratopathyOcular surface environment

Identifiers

PMID33435910
PMCPMC7801561
OpenAlexW3118996534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.