ArticleBMC cardiovascular disorders2021
Predictors of mortality and adverse events in patients with infective endocarditis: a retrospective real world study in a surgical centre.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Postoperative Treatment Regimens in Patients With Native Valve Endocarditis due toOpen forum infectious diseases · 2025Trial
- Risk Factors Associated With Positive Intraoperative Valve Tissue Cultures and the Subsequent Impact on Infective Endocarditis Management and Outcomes.Open forum infectious diseases · 2026Article
- Epidemiology of bloodstream infections and infective endocarditis: new insights on typical species and echocardiography screening.Open heart · 2026Article
- Infective Endocarditis in Ireland: A Nationwide Analysis.Journal of clinical medicine · 2026Article
- Reconstruction of the Aorto-Mitral Curtain in Complex Infective Endocarditis: A Contemporary Narrative Review of the Commando Procedure.Reviews in cardiovascular medicine · 2026Review
- Association between prothrombin time activity and short-term outcomes in patients with infective endocarditis.BMC infectious diseases · 2026Article
- Ceftobiprole alone versus ampicillin-ceftriaxone against borderline-penicillin-resistant, ampicillin-susceptible, and vancomycin-resistantAntimicrobial agents and chemotherapy · 2026Article
- Patients with multivalvular infective endocarditis demonstrate adverse cardiac remodeling before surgery with increased postoperative mortality risk.Journal of thoracic disease · 2025Article
- Syphilitic Mitral Valve Endocarditis: Diagnostic Challenges and Clinical Management.JACC. Case reports · 2025Article
- Review
- Epidemiology of community acquired and health care assocİated infective endocarditis and 28 day mortality risk factors: a university hospital study.BMC infectious diseases · 2025Article
- Native Triple-Valve Endocarditis Caused by Corynebacterium striatum Needing Urgent Surgery.JACC. Case reports · 2025Article
- Comparison of ceftriaxone versus ceftaroline in combination with ampicillin or penicillin againstMicrobiology spectrum · 2025Article
- Epidemiological, clinical and microbiological aspects of infective endocarditis in Türkiye.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Tricuspid Valve Infective Endocarditis in a Chronic Haemodialysis Patient with a Hickman Catheter: A Case Report.Pathogens (Basel, Switzerland) · 2025Article
- Early and Long-Term Outcomes of Patients Undergoing Surgery for Native and Prosthetic Valve Endocarditis: The Role of Preoperative Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Platelet Ratio, and Monocyte-to Lymphocyte Ratio.Journal of clinical medicine · 2025Article
- Article
- ACEF score and lactate: lifeline predictors in endocarditis valve procedures: insights from a single-center study.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Infective Endocarditis Among Women Who Inject Drugs.JAMA network open · 2024Article
- Clinical Characterization of Pathogens, Risk Factors and Quality of Life in an Observational Study of Native vs. Prosthetic Aortic Valve Endocarditis Surgery.Life (Basel, Switzerland) · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMortality in infective endocarditis (IE) is still high, and the long term prognosis remains uncertain. This study aimed to identify predictors of long-term mortality for any cause, adverse event rate, relapse rate, valvular and ventricular dysfunction at follow-up, in a real-world surgical centre.
methodsWe retrospectively analyzed 363 consecutive episodes of IE (123 women, 34%) admitted to our department with a definite diagnosis of non-device-related IE. Median follow-up duration was 2.9 years. Primary endpoints were predictors of mortality, recurrent endocarditis, and major non-fatal adverse events (hospitalization for any cardiovascular cause, pace-maker implantation, new onset of atrial fibrillation, sternal dehiscence), and ventricular and valvular dysfunction at follow-up.
resultsMultivariate analysis independent predictors of mortality showed age (HR per unit 1.031, p < 0.003), drug abuse (HR 3.5, p < 0.002), EUROSCORE II (HR per unit 1.017, p < 0.0006) and double valve infection (HR 2.3, p < 0.001) to be independent predictors of mortality, while streptococcal infection remained associated with a better prognosis (HR 0.5, p < 0.04). Major non-fatal adverse events were associated with age (HR 1.4, p < 0.022). New episodes of infection were correlated with S aureus infection (HR 4.8, p < 0.001), right-sided endocarditis (HR 7.4, p < 0.001), spondylodiscitis (HR 6.8, p < 0.004) and intravenous drug abuse (HR 10.3, p < 0.001). After multivariate analysis, only drug abuse was an independent predictor of new episodes of endocarditis (HR 8.5, p < 0.001). Echocardiographic follow-up, available in 95 cases, showed a worsening of left ventricular systolic function (p < 0.007); severe valvular dysfunction at follow-up was reported only in 4 patients, all of them had mitral IE (p < 0.03).
conclusionsThe present study highlights some clinical, readily available factors that can be useful to stratify the prognosis of patients with IE.
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