ArticleBMC cardiovascular disorders2021
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
- Carbohydrate Reduction and a Holistic Model of Care in Diabetes Management: Insights from a Retrospective Multi-Year Audit in New Zealand.Nutrients · 2025Observational
- A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein.Scientific reports · 2025Article
- Machine Learning Model for Predicting Risk Factors of Prolonged Length of Hospital Stay in Patients with Aortic Dissection: a Retrospective Clinical Study.Journal of cardiovascular translational research · 2025Article
- Research on the clinical factors of cardiac iron deposition in children with beta-thalassemia major.European journal of pediatrics · 2024Article
- [Risk factors of early myocardial injury and the impact of early myocardial injury on prognosis of patients with extensive burns].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Postoperative Alanine Aminotransferase Levels Are Associated with Outcomes in Pediatric Patients Undergoing Total Cavopulmonary Connection.Children (Basel, Switzerland) · 2022Article
- Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women.Aging medicine (Milton (N.S.W)) · 2022Article
- The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study.Cardiovascular diabetology · 2022Article
- Association between serum alanine and aspartate aminotransferase and blood pressure: a cross-sectional study of Chinese freshmen.BMC cardiovascular disorders · 2021Article
- Association of theDiagnostics (Basel, Switzerland) · 2021Article
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Abstract
backgroundHigh and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population.
methodsCross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP).
resultsAbnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88-1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86-0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found.
conclusionThis study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies.
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