Evidence map›Paper›PMID 33435798›Full record

ArticleAutophagy2021

An organelle-directed chemical ligation approach enables dual-color detection of mitophagy.

Yilong Shi, Xiaoxue Zou, Shixiong Wen, Lei Gao, Jian Li, Jiahuai Han, Shoufa Han

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Bioorthogonal Chemistry in Cellular Organelles.Topics in current chemistry (Cham) · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yilong ShiState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
Xiaoxue ZouDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory for Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, China.
Shixiong WenState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
Lei GaoDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory for Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, China.
Jian LiDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory for Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, China.
Jiahuai HanState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
Shoufa HanDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory for Physical Chemistry of Solid Surfaces, the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, China.
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunctional organelles and defective turnover of organelles are engaged in multiple human diseases, but are elusive to image with conventional organelle probes. To overcome this, we developed intra-mitochondrial CLICK to assess mitophagy (IMCLAM), using a pair of conventional ΔΨm probes, where each probe alone fails to track dysfunctional mitochondria. The

Indexed as

AnimalsAutophagy-Related Protein 5Cells, CulturedFluorescent DyesGene Knockout TechniquesHeLa CellsHumansIn Vitro TechniquesMCF-7 CellsMelanoma, ExperimentalMembrane Potential, MitochondrialMiceMicroscopy, Fluorescence, MultiphotonMitochondriaMitophagyOrganellesAtg5 protein, mouseAutophagy-Related Protein 5Fluorescent DyesBioorthogonal reactiondysfunctional organellefluorescence-on imagingmitophagymitophagy inducer

Identifiers

PMID33435798
PMCPMC8632332
OpenAlexW3118951056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.