Evidence map›Paper›PMID 33435730›Full record

ArticleCirculation. Cardiovascular quality and outcomes2021

Patient-Perceived Versus Actual Risk of Cardiovascular Disease and Associated Willingness to Consider and Use Prevention Therapy.

Ann Marie Navar, Tracy Y Wang, Shuang Li, Xiaojuan Mi, Zhuokai Li, Jennifer G Robinson, Salim S Virani, Eric D Peterson

Abstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  4. Validation of Risk Perception Cut-Offs in Italian Brief PRHDS (PRHDS-BI): Implications for Primary Cardiovascular Prevention.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Observational
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  19. Psychometric Properties of a Brief Version of the Perception of Risk of Heart Disease Scale in an Italian Sample.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ann Marie NavarDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).
Tracy Y WangDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).
Shuang LiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).
Xiaojuan MiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).
Zhuokai LiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).
Jennifer G RobinsonUniversity of Iowa (J.G.R.).
Salim S ViraniBaylor College of Medicine, Houston, TX (S.S.V.).
Eric D PetersonDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (A.M.N., T.Y.W., S.L., X.M., Z.L., E.D.P.).

Funding

Preventing Cardiovascular Disease through Improved Risk Prediction and CommunicationK01HL133416 · NHLBI · DUKE UNIVERSITY · PI NAVAR, ANN MARIE · 2016 to 2020
$707k
NHLBI NIH HHS K01 HL133416
6 · The paper itself

Abstract

backgroundCardiovascular prevention guidelines use estimated 10-year atherosclerotic cardiovascular disease (CVD) risk based on the pooled cohort equations to guide treatment decisions and engage patients in shared decision-making. We sought to determine patient perceived versus actual risk of atherosclerotic CVD and associations with willingness for preventive therapy.

methodsWe evaluated calculated and perceived CVD risk among 4187 patients across 124 sites in the Patient and Provider Assessment of Lipid Management Registry. Ten-year risk was assessed using the pooled cohort equations; risk relative-to-peers was determined based on age-, sex-, and race-based percentiles; and patient estimates of risk were assessed using patient surveys. Poisson regression models evaluated associations between risk estimates, statin use, and willingness to take prevention therapy.

resultsOverall, there was no correlation between patients' estimates of their 10-year CVD risk and calculated 10-year risk (ρ=-0.01,

conclusionsWhen asked, most patients overestimate their 10-year risk but hold an optimistic bias of their risk relative to age-, race-, and sex-matched peers. Providing accurate absolute risk assessments to patients without proper context may paradoxically decrease many patients' perceived risk of CVD, thereby disincentivizing initiation of CVD risk reduction therapy.

Indexed as

Cardiovascular DiseasesAgedAtherosclerosisCohort StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedRisk AssessmentRisk FactorsHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseaseslipidsriskrisk assessment

Identifiers

PMID33435730
PMCPMC7855929

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.