Evidence map›Paper›PMID 33435590›Full record

ArticleBiomedicines2021

Role of BRCA Mutation and HE4 in Predicting Chemotherapy Response in Ovarian Cancer: A Retrospective Pilot Study.

Francesco Plotti, Corrado Terranova, Federica Guzzo, Carlo De Cicco Nardone, Daniela Luvero, Martina Bartolone, Camilla Dionisi, Domenico Benvenuto, Silvia Fabris, Massimo Ciccozzi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in oncology · 2021
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Francesco PlottiDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Corrado TerranovaDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Federica GuzzoDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Carlo De Cicco NardoneDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Daniela LuveroDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Martina BartoloneDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Camilla DionisiDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Domenico BenvenutoUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Silvia FabrisUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Violante Di DonatoDepartment of Gynecology, Obstetrics and Urology, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Pierluigi Benedetti PaniciDepartment of Gynecology, Obstetrics and Urology, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.
Roberto AngioliDepartment of Obstetrics and Gynecology, University ''Campus Bio-Medico'' of Rome, Via Alvaro del Portillo, 200-00128 Rome, Italy.
Università Campus Bio-Medico · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even though 80% of patients with High-Grade Serous Ovarian Cancer respond to standard first-line chemotherapy, a majority of them could relapse in the following five years due to a resistance to platinum. Human Epididymis protein 4 (HE4) is one of the most promising markers in predicting platinum therapy response. This pilot study aims to evaluate the potential role of HE4 value in predicting chemotherapy response in

Indexed as

BRCAchemotherapy responseHE4ovarian cancer

Identifiers

PMID33435590
PMCPMC7827362
OpenAlexW3120293244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.