Evidence map›Paper›PMID 33435582›Full record

ArticleInternational journal of molecular sciences2021

Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.

Birgit Rath-Deschner, Andressa Vilas Boas Nogueira, Svenja Memmert, Marjan Nokhbehsaim, Joni Augusto Cirelli, Sigrun Eick, Nicolai Miosge, Christian Kirschneck, Marco Kesting, James Deschner and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  15. Obesity Modifies the Proteomic Profile of the Periodontal Ligament.International journal of molecular sciences · 2023
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Birgit Rath-DeschnerDepartment of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Andressa Vilas Boas NogueiraDepartment of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.ORCID 0000-0002-2756-5947
Svenja MemmertDepartment of Orthodontics and Section of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.ORCID 0000-0002-8153-6610
Marjan NokhbehsaimSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Joni Augusto CirelliDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University, UNESP, Araraquara 14801-903, Brazil.
Sigrun EickDepartment of Periodontology, Laboratory for Oral Microbiology, zmk bern, Zahnmedizinische Kliniken, 53010 Bern, Switzerland.ORCID 0000-0002-4619-2461
Nicolai MiosgeDepartment of Prosthodontics, University Medical Center, 37075 Goettingen, Germany.
Christian KirschneckDepartment of Orthodontics, University of Regensburg, 93053 Regensburg, Germany.
Marco KestingDepartment of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
James DeschnerDepartment of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.
Andreas JägerDepartment of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, 53111 Bonn, Germany.
Anna DamanakiDepartment of Periodontology and Operative Dentistry, University Medical Center, University of Mainz, 55131 Mainz, Germany.ORCID 0000-0002-2706-398X
University of Bonn · DEJohannes Gutenberg University Mainz · DECentro Universitário de Araraquara · BRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Regensburg · DE

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.144012/2017-01Deutsche Forschungsgemeinschaft DE1593/5-1Deutscher Akademischer Austauschdienst 57391253German Society of Orthodontics noneSão Paulo Research Foundation 2017/07137-2
6 · The paper itself

Abstract

The aim of the study was to clarify whether orthodontic forces and periodontitis interact with respect to the anti-apoptotic molecules superoxide dismutase 2 (SOD2) and baculoviral IAP repeat-containing protein 3 (BIRC3). SOD2, BIRC3, and the apoptotic markers caspases 3 (CASP3) and 9 (CASP9) were analyzed in gingiva from periodontally healthy and periodontitis subjects by real-time PCR and immunohistochemistry. SOD2 and BIRC3 were also studied in gingiva from rats with experimental periodontitis and/or orthodontic tooth movement. Additionally, SOD2 and BIRC3 levels were examined in human periodontal fibroblasts incubated with

Indexed as

Gene Expression RegulationAnimalsApoptosisBaculoviral IAP Repeat-Containing 3 ProteinCaspase 3Caspase 9Cells, CulturedFibroblastsFusobacterium nucleatumGingivaHost-Pathogen InteractionsHumansPeriodontal LigamentPeriodontiumRatsSuperoxide DismutaseBaculoviral IAP Repeat-Containing 3 ProteinCaspase 3Caspase 9Superoxide DismutaseSuperoxide Dismutase 2Fusobacterium nucleatumgingivitisorthodontic tooth movementperiodontal ligamentperiodontitisperiodontium

Identifiers

PMID33435582
PMCPMC7827060
OpenAlexW3120535588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.