ReviewDiagnostics (Basel, Switzerland)2021
The Effects of COVID-19 on Placenta and Pregnancy: What Do We Know So Far?
Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern.Placenta · 2022Pooled it
- Review
- SARS-CoV-2 infects human primary cytotrophoblasts mainly through a non-canonical entry route.Molecular human reproduction · 2026Article
- SARS-CoV-2 delta and omicron variants alter trophoblast cell fusion and syncytiotrophoblast dynamics: new insights into placental vulnerability.Cell death & disease · 2025Article
- Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan.Archives of Razi Institute · 2025Article
- The pregnancy outcomes of women with SARS-CoV-2 infection in the first trimester ---a longitudinal cohort study.BMC pregnancy and childbirth · 2025Article
- Association ofViruses · 2024Article
- SARS-CoV-2 Infection during Delivery Causes Histopathological Changes in the Placenta.Diseases (Basel, Switzerland) · 2024Article
- Impact of COVID-19 disease on placental histopathology. PLAXAVID study.Histology and histopathology · 2024Observational
- The psychosocial experiences of pregnant women in the early stages of the COVID-19 pandemic: A retrospective qualitative study.PloS one · 2024Article
- Factors associated with hospitalizations and deaths of pregnant women from Paraná due to COVID-19: a cross-sectional study.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Observational
- Article
- Intrauterine transmission of SARS-CoV-2 to and prenatal ultrasound abnormal findings in the fetus of a pregnant woman with mild COVID-19.BMC pregnancy and childbirth · 2023Article
- A History of COVID-19 in Pregnancy: A Narrative Review.Journal of clinical medicine · 2023Review
- Effect of SARS-CoV-2 Infection and COVID-19 Vaccination on Oxidative Status of Human Placenta: A Preliminary Study.Antioxidants (Basel, Switzerland) · 2023Article
- Inflammation and Immune Reactions in the Fetus as a Response to COVID-19 in the Mother.Journal of clinical medicine · 2023Article
- Pregnancy and COVID-19: past, present and future.Obstetrics & gynecology science · 2023Article
- SARS-CoV-2 Footprints in the Placenta: What We Know after Three Years of the Pandemic.Journal of personalized medicine · 2023Review
- Association of Pre-Pregnancy Obesity and COVID-19 with Poor Pregnancy Outcome.Journal of clinical medicine · 2023Article
- Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord blood.Metabolomics : Official journal of the Metabolomic Society · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has inflicted a serious health crisis globally. This virus is associated with a spectrum of respiratory illness ranging from asymptomatic, mild to severe pneumonia, and acute respiratory distress syndrome. Accumulating evidence supports that COVID-19 is not merely a respiratory illness per se, but potentially affects other organ systems including the placenta. SARS-CoV-2 gains access to human cells via angiotensin-converting enzyme 2 (ACE-2). The abundance of ACE-2 on the placental cell surface, especially the syncytiotrophoblasts, could potentially contribute to vertical transplacental transmission to the fetus following maternal COVID-19 infection. Intriguingly, despite the placentas being tested positive for SARS-CoV-2, there are very few newborns that manifest virus-induced diseases. The protective effects of the placental barrier to viral infection, limiting the spread of the virus to newborn infants, remain a mystery. The detrimental role of COVID-19 in pregnancies is largely debatable, although COVID-19 maternal infection has been implicated in unfavorable pregnancy outcomes. In this review, we summarize the pathological features manifested in placenta due to COVID-19 maternal infection that have been previously reported, and relate them to the possible disease manifestation. The potential mechanistic pathways associated with transplacental viral transmission and adverse pregnancy outcomes are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.