Artificial Caries Lesion Characteristics after Secondary Demineralization with Theobromine-Containing Protocol.

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 53% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

The Effect of Different White Spot Lesion Treatments on the Enamel Microhardness-An In Vitro Pilot Study.Dentistry journal · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Hani M NassarDepartment of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, P.O. Box 80209, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-6241-1118

Frank LippertDepartment of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, 415 Lancing Street, Indianapolis, IN 46202, USA.ORCID 0000-0003-1944-2960

Indiana University – Purdue University Indianapolis · USKing Abdulaziz University · SA

Funding

Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia J-1436-165-38

6 · The paper itself

Abstract

Developing artificial caries lesions with varying characteristics is needed to adequately study caries process in vitro. The objective of this study was to investigate artificial caries lesion characteristics after secondary demineralization protocol containing theobromine and fluoride. Sixty bovine enamel slabs (4 × 3 mm) were demineralized using a Carbopol-containing protocol for 6 days. A baseline area (2 × 3 mm) was protected with acid-resistant nail varnish, after which specimens were exposed for 24 h to a secondary demineralization protocol containing acetic acid plus one of four fluoride/theobromine combinations (

Indexed as

AnimalsBronchodilator AgentsCattleDental CariesDental EnamelFluoridesTheobromineToothTooth DemineralizationBronchodilator AgentsFluoridesTheobrominecariesdemineralizationfluoridetheobrominetransverse microradiography

Identifiers

PMID33435546

DOI10.3390/molecules26020300

PMCPMC7827480

OpenAlexW3120399052

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.