ArticlePharmaceutics2021
Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Pharmacokinetics and Drug Interactions.Pharmaceutics · 2026Article
- The protective effects and mechanisms of rosmarinic acid againstFrontiers in pharmacology · 2025Article
- Article
- In Vitro Metabolism and Transport Characteristics of Zastaprazan.Pharmaceutics · 2024Article
- Article
- NIR-II live imaging study on the degradation pattern of collagen in the mouse model.Regenerative biomaterials · 2023Article
- Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review.Pharmaceutics · 2022Review
- Toxicokinetics of β-Amanitin in Mice and In Vitro Drug-Drug Interaction Potential.Pharmaceutics · 2022Article
- Molecular Basis Underlying Hepatobiliary and Renal Excretion of Phenolic Acids ofFrontiers in pharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier transporters and also in rats. Intravenously injected rosmarinic acid showed bi-exponential decay and unchanged rosmarinic acid was mainly eliminated by urinary excretion, suggesting the involvement of transporters in its renal excretion. Rosmarinic acid showed organic anion transporter (OAT)1-mediated active transport with a K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.