ArticlePharmaceuticals (Basel, Switzerland)2021
The Influence of Body Composition on the Systemic Exposure of Paclitaxel in Esophageal Cancer Patients.
Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Exploratory analysis of the association between body composition albumin-bound paclitaxel induced peripheral neuropathy.Frontiers in pharmacology · 2026Article
- Review
- Muscle mass affects paclitaxel systemic exposure and may inform personalized paclitaxel dosing.British journal of clinical pharmacology · 2022Article
- The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.Journal of cachexia, sarcopenia and muscle · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in body composition are associated with chemotherapy-related toxicities and effectiveness of treatment. It is hypothesized that the pharmacokinetics (PK) of chemotherapeutics may depend on body composition. The effects of body composition on the variability of paclitaxel PK were studied in patients with esophageal cancer. Skeletal muscle index (SMI), visceral adipose tissue (VAT), and skeletal muscle density (SMD) were measured at the third lumbar vertebra on computed tomography (CT) scans performed before treatment. Paclitaxel PK data were collected from a prospective study performed between May 2004 and January 2014. Non-linear mixed-effects modeling was used to fit paclitaxel PK profiles and evaluate the covariates body surface area (BSA), SMI, VAT, and SMD using a significance threshold of
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