Evidence map›Paper›PMID 33435434›Full record

ArticleBiology2021

Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line.

Edgar Tavares-da-Silva, Eurico Pereira, Ana S Pires, Ana R Neves, Catarina Braz-Guilherme, Inês A Marques, Ana M Abrantes, Ana C Gonçalves, Francisco Caramelo, Rafael Silva-Teixeira and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Edgar Tavares-da-SilvaFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-8612-0147
Eurico PereiraClinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.ORCID 0000-0002-6532-2989
Ana S PiresCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7994-4650
Ana R NevesClinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.
Catarina Braz-GuilhermeClinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.
Inês A MarquesCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-5690-3020
Ana M AbrantesCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.
Ana C GonçalvesCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.
Francisco CarameloClinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.ORCID 0000-0002-0015-8604
Rafael Silva-TeixeiraClinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.
Fernando MendesCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-5205-8939
Arnaldo FigueiredoFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-548 Coimbra, Portugal.
Maria Filomena BotelhoCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7202-1650
University of Coimbra · PTHospitais da Universidade de Coimbra · PTUniversidade do Porto · PT

Funding

Fundação para a Ciência e a Tecnologia UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020 (CIBB) and SFRH/BD/136973/2018JABA RECORDATI and Associação Portuguesa de Urologia Bolsa de Investigação JABA RECORDATI Urologia 2017
6 · The paper itself

Abstract

Antitumor therapies based on Cold Atmospheric Plasma (CAP) are an emerging medical field. In this work, we evaluated CAP effects on bladder cancer. Two bladder cancer cell lines were used, HT-1376 (stage III) and TCCSUP (stage IV). Cell proliferation assays were performed evaluating metabolic activity (MTT assay) and protein content (SRB assay). Cell viability, cell cycle, and mitochondrial membrane potential (Δψ

Indexed as

bladder cancercell deathcold atmospheric plasmaplasma medicinereactive oxygen and nitrogen species

Identifiers

PMID33435434
PMCPMC7828061
OpenAlexW3120780065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.