Evidence map›Paper›PMID 33435417›Full record

ArticleInternational journal of molecular sciences2021

2-(2-Methyl-2-nitrovinyl)furan but Not Furvina Interfere with

Diana Oliveira, Anabela Borges, Reinaldo Molina Ruiz, Zenaida Rodríguez Negrín, Simona Distinto, Fernanda Borges, Manuel Simões

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Antibiotics (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Biofilm · 2024
    Review
  4. Review
  5. Article
  6. Labdane Diterpenoids fromMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Diana OliveiraLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.ORCID 0000-0001-9409-3276
Anabela BorgesLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.ORCID 0000-0001-6929-6805
Reinaldo Molina RuizCentro de Bioactivos Quimico, Universidad Central de las Villas, 54830 Santa Clara, Cuba.ORCID 0000-0001-5098-5432
Zenaida Rodríguez NegrínCentro de Bioactivos Quimico, Universidad Central de las Villas, 54830 Santa Clara, Cuba.
Simona DistintoDepartment of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
Fernanda BorgesCIQUP-Research Center in Chemistry, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0003-1050-2402
Manuel SimõesLEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.ORCID 0000-0002-3355-4398
Universidade do Porto · PTUniversidad Central "Marta Abreu" de las Villas (UCLV) · CUUniversity of Cagliari · IT

Funding

Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-030219, POCI-01-0247-FEDER-035234; POCI-01-0145-FEDER-028397; POCI-01-0145-FEDER-006939
6 · The paper itself

Abstract

Quorum sensing (QS) plays an essential role in the production of virulence factors, in biofilm formation and antimicrobial resistance. Consequently, inhibiting QS is being considered a promising target for antipathogenic/anti-virulence therapies. This study aims to screen 2-nitrovinylfuran derivatives structurally related to Furvina (a broad-spectrum antibiotic already used for therapeutic purposes) for their effects on QS and in biofilm prevention/control. Furvina and four 2-nitrovinylfuran derivatives (compounds

Indexed as

Anti-Bacterial AgentsBiofilmsDrug SynergismFuransFusidic AcidHumansMethylationMolecular Docking SimulationQuorum SensingStaphylococcal InfectionsStaphylococcus aureusVinyl Compounds2-bromo-5-(2-bromo-2-nitrovinyl)furanAnti-Bacterial AgentsFuransFusidic Acidtrans-2-(2-nitrovinyl)furanVinyl Compounds2-nitrovinylfuran derivativesantimicrobial combinationantimicrobial resistancebiofilmsFurvinaquorum-sensing inhibitionStaphylococcus aureus

Identifiers

PMID33435417
PMCPMC7827229
OpenAlexW3119771493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.