ArticleNutrients2021
Association between Time Restricted Feeding and Cognitive Status in Older Italian Adults.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The cross-sectional and prospective associations between time-restricted eating and cardiometabolic health in community-dwelling adults: A systematic review and meta-analysis of observational studies.European journal of clinical nutrition · 2026Pooled it
- Pooled it
- Chemotherapy-related cognitive impairment and non-pharmacological interventions targeting the nervous system: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Trial
- Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial.Frontiers in public health · 2023Trial
- Brain health strategies in middle-aged individuals with mild neurocognitive disorder: a scoping review.The journal of prevention of Alzheimer's disease · 2026Review
- The Need for Standardized Data Collection to Improve Harmonization and Pooling of Information About Modifiable Risk Factors for Alzheimer's Diseases in Italian Clinical Studies: A Systematic Review.Geriatrics (Basel, Switzerland) · 2026Review
- Association of nighttime fasting duration, breakfast time and dinner time with healthy aging in Chinese older adults: a cross‑sectional study.Nutrition journal · 2026Article
- Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice.Neurobiology of aging · 2026Article
- Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty.Frontiers in nutrition · 2026Review
- Time-restricted eating in Alzheimer's disease: TREAD pilot trial design.Contemporary clinical trials communications · 2025Article
- Article
- Associations Between Chrono-Nutrition Behaviours and Cognitive Function in Middle-Aged Adults: The NUTRICO Cross-Sectional Cohort Study.Nutrition bulletin · 2025Article
- Time-restricted feeding mitigates Alzheimer's disease-associated cognitive impairments via aiMeta · 2025Article
- Time-restricted eating as a potential strategy for healthy lifespan: an evaluation of current evidence.Frontiers in medicine · 2025Review
- The interactions between energy homeostasis and neurovascular plasticity.Nature reviews. Endocrinology · 2024Review
- Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings.PNAS nexus · 2024Review
- Meal Timing and Depression Among Chinese Children and Adolescents: Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- Interaction of Cooking-Generated Aerosols on the Human Nervous System and the Impact of Caloric Restriction Post-Exposure.Nutrients · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to the increased life expectancy, the prevalence of aging-related health conditions, such as cognitive impairment, dementia and Alzheimer's disease is increasing. Among the modifiable risk factors, dietary factors have proved to be of primary importance in preserving and improving mental health and cognitive status in older adults, possibly through the modulation of adult neurogenesis, neuronal plasticity and brain signaling. Feeding/fasting timing manipulation has emerged as an innovative strategy to counteract and treat cognitive decline. The aim of this study was to investigate the association between the timing of the feeding period and cognitive status in a cross-sectional cohort of adults living in the Mediterranean area.
methodsDemographic and dietary characteristics of 883 adults living in Southern Italy (Sicily) were analyzed. Food frequency questionnaires were used to calculate the time window between the first and the last meal of an average day. Participants with an eating time window duration of more than 10 h were then identified, as well as those with eating time restricted to less than 10 h (TRF).
resultsAfter adjusting for potential confounding factors, individuals adherent to TRF were less likely to have cognitive impairment, compared to those with no eating time restrictions [odds ratio (OR) = 0.28; 95% confidence intervals (CI): 0.07-0.90]; a similar association was found for individuals having breakfast (OR = 0.37, 95% CI: 0.16-0.89), but not for those having dinner.
conclusionsThe results of this study reveal that time restricted eating may be positively associated with cognitive status, and thus exert plausible effects on brain health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.