Evidence map›Paper›PMID 33435412›Full record

ArticleCurrent oncology (Toronto, Ont.)2021

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatric Patients.

Sébastien Perreault, Rose Chami, Rebecca J Deyell, Dina El Demellawy, Benjamin Ellezam, Nada Jabado, Daniel A Morgenstern, Aru Narendran, Poul H B Sorensen, Jonathan D Wasserman and 1 more

Open access · goldAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. TRK inhibitors in pediatric gliomas.Neuro-oncology advances · 2026
    Review
  3. Review
  4. Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Management of adverse events related to first-generation tyrosine receptor kinase inhibitors in adults: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Review
  9. Limited Accuracy of Pan-Trk Immunohistochemistry Screening forInternational journal of molecular sciences · 2022
    Article
  10. Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas.Laboratory investigation; a journal of technical methods and pathology · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Diagnostics (Basel, Switzerland) · 2021
    Review
  18. Review
  19. Brazilian Expert Consensus for NTRK Gene Fusion Testing in Solid Tumors.Clinical pathology (Thousand Oaks, Ventura County, Calif.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Sébastien PerreaultDepartment of Neurosciences, Division of Child Neurology CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Rose ChamiDepartment of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Rebecca J DeyellDivision of Pediatric Hematology, Oncology and Bone Marrow Transplant, British Columbia Children's Hospital and Research Institute, Vancouver, BC V6H 3N1, Canada.
Dina El DemellawyPathology Department, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.
Benjamin EllezamDepartment of Pathology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, QC H3T 1C5, Canada.ORCID 0000-0002-8716-7924
Nada JabadoDepartment of Pediatric Hematology-Oncology, MUHC, Montreal, QC H4A 3J1, Canada.
Daniel A MorgensternDivision of Pediatric Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.ORCID 0000-0002-4859-1108
Aru NarendranDepartments of Pediatrics, Oncology and, Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Poul H B SorensenDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Jonathan D WassermanDivision of Endocrinology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.ORCID 0000-0001-7088-8146
Stephen YipDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-8514-9861
University of Toronto · CACentre Hospitalier Universitaire Sainte-Justine · CAUniversity of British Columbia · CABC Children's Hospital · CAChildren's Hospital of Eastern Ontario · CAMontreal Clinical Research Institute · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophic tyrosine receptor kinase gene fusions (

Indexed as

NeoplasmsReceptor, trkABiomarkersCanadaChildConsensusHumansOncogene Proteins, FusionBiomarkersOncogene Proteins, FusionReceptor, trkAentrectiniblarotrectinibmolecular testingNTRKoncogenic driverstargeted therapyTRK fusiontumour-agnostic

Identifiers

PMID33435412
PMCPMC7903261
OpenAlexW3120793202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.