Evidence map›Paper›PMID 33435380›Full record

ArticleMolecules (Basel, Switzerland)2021

Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.

Weirui Zhang, Yuping Zhu, Haobing Yu, Xiaoyu Liu, Binghua Jiao, Xiaoling Lu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. The Importance of Thioredoxin-1 in Health and Disease.Antioxidants (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Review
  12. Pimarane Diterpenes from Fungi.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Weirui ZhangCollege of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China.ORCID 0000-0001-7164-1700
Yuping ZhuCollege of Basic Medical Sciences, Experimental Teacher Center, Naval Medical University, Shanghai 200433, China.
Haobing YuCollege of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China.ORCID 0000-0003-0516-4664
Xiaoyu LiuCollege of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China.
Binghua JiaoCollege of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China.
Xiaoling LuCollege of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China.
Second Military Medical University · CN

Funding

National Key Research and Development Project 2019YFC0312504Natural Science Foundation of Shanghai 20ZR1470600Shanghai Pujiang Program 2020PJD082
6 · The paper itself

Abstract

Libertellenone H (LH), a marine-derived pimarane diterpenoid isolated from arctic fungus

Indexed as

Antineoplastic AgentsApoptosisAscomycotaBiological ProductsCell ProliferationDiterpenesDrug Screening Assays, AntitumorHumansPancreatic NeoplasmsReactive Oxygen SpeciesThioredoxinsTumor Cells, CulturedAntineoplastic AgentsBiological ProductsDiterpeneslibertellenone HReactive Oxygen SpeciesThioredoxinsTXN protein, humanapoptosisLibertellenone Hpancreatic cancerROSTrx system

Identifiers

PMID33435380
PMCPMC7827531
OpenAlexW3118707229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.