Evidence map›Paper›PMID 33435331›Full record

ArticleInternational journal of molecular sciences2021

Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo.

Fanpeng Zhao, Quillan Austria, Wenzhang Wang, Xiongwei Zhu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fanpeng ZhaoDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-6441-7938
Quillan AustriaDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Wenzhang WangDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Xiongwei ZhuDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-2092-6508
Case Western Reserve University · US

Funding

Abnormal Mitochondrial Dynamics and Mitochondrial Dysfunction in Alzheimer's DiseR01NS083385 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIONGWEI · 2013 to 2017
$2.1M
Epigenomic Mechanism of Parkinson's DiseaseR01NS083498 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIONGWEI · 2013 to 2015
$604k
NIH HHS NS083385 and NS083498NINDS NIH HHS R01 NS083385NINDS NIH HHS R01 NS083498
6 · The paper itself

Abstract

Mitochondrial dysfunction represents a critical event in the pathogenesis of Parkinson's disease (PD). Increasing evidence demonstrates that disturbed mitochondrial dynamics and quality control play an important role in mitochondrial dysfunction in PD. Our previous study demonstrated that MPP

Indexed as

Up-RegulationAnimalsCorpus StriatumDisease Models, AnimalDopaminergic NeuronsFemaleGTP PhosphohydrolasesMaleMiceMice, TransgenicMitochondrial DynamicsMitochondrial ProteinsOxidative StressParkinsonian DisordersGTP PhosphohydrolasesMFN2 protein, humanMitochondrial ProteinsMfn2mitochondrial dynamicsMPTPneurodegenerationParkinson’s disease

Identifiers

PMID33435331
PMCPMC7827738
OpenAlexW3120780474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.