ReviewInternational journal of environmental research and public health2021
The Bayesian Design of Adaptive Clinical Trials.
Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A systematic review of sample size determination in Bayesian randomized clinical trials: full Bayesian methods are rarely used.BMC medical research methodology · 2026Pooled it
- Pooled it
- Basket trials in rare diseases: a systematic review of current practices, methodological challenges, and future directions.Orphanet journal of rare diseases · 2025Pooled it
- Adaptive designs in clinical trials: a systematic review-part I.BMC medical research methodology · 2024Pooled it
- Characteristics, Progression, and Output of Randomized Platform Trials: A Systematic Review.JAMA network open · 2024Pooled it
- A systematic review of randomised controlled trials with adaptive and traditional group sequential designs - applications in cardiovascular clinical trials.BMC medical research methodology · 2023Pooled it
- Data Analysis Planning and Reporting for Confirmatory Multi-Lab Preclinical Trials: A Tutorial.Biometrical journal. Biometrische Zeitschrift · 2026Review
- The Future of Obesity Care: Exploring Synergies Between Metabolic Bariatric Surgery, Interventional Endoscopy and Pharmacotherapy.Obesity surgery · 2026Review
- Comparative evaluation of Bayesian external information borrowing and frequentist approaches in underpowered confirmatory trials.BMC medical research methodology · 2026Article
- Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework.Frontiers in public health · 2026Review
- Bayesian Response-Adaptive Randomization for Cluster Randomized Controlled Trials.Statistics in medicine · 2026Article
- Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study.BMC medical research methodology · 2025Article
- Pulsed field ablation vs sham ablation to treat atrial fibrillation (the PFA-SHAM trial).Heart rhythm O2 · 2025Article
- An Approach to Design Adaptive Clinical Trials With Time-to-Event Outcomes Based on a General Bayesian Posterior Distribution.Statistics in medicine · 2025Article
- Properties of adaptive, cluster-randomised controlled trials with few clusters: a simulation study.Implementation science : IS · 2025Article
- Prasinezumab: A Bayesian Perspective on Its Efficacy.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Establishment of a machine learning model for predicting splenic hilar lymph node metastasis.NPJ digital medicine · 2025Article
- Implementation of statistical features of a Bayesian two-armed responsive adaptive randomization trial with post hoc analysis of time trend drift.Journal of biopharmaceutical statistics · 2025Article
- A tutorial on the what, why, and how of Bayesian analysis: Estimating mood and anxiety disorder prevalence using a Canadian data linkage study.PLOS mental health · 2025Article
- Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper presents a brief overview of the recent literature on adaptive design of clinical trials from a Bayesian perspective for statistically not so sophisticated readers. Adaptive designs are attracting a keen interest in several disciplines, from a theoretical viewpoint and also-potentially-from a practical one, and Bayesian adaptive designs, in particular, have raised high expectations in clinical trials. The main conceptual tools are highlighted here, with a mention of several trial designs proposed in the literature that use these methods, including some of the registered Bayesian adaptive trials to this date. This review aims at complementing the existing ones on this topic, pointing at further interesting reading material.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.