ArticleBiomedicines2021
Does Platelet-Rich Fibrin Enhance the Early Angiogenetic Potential of Different Bone Substitute Materials? An In Vitro and In Vivo Analysis.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- [Evaluation of the clinical effect of concentrated growth factor combined with sticky bone in maxillary anterior alveolar ridge preservation].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Trial
- Platelet-Rich Fibrin Induces New Bone Formation to Promote Extreme Lateral Interbody Fusion of Spine in Rabbits.JOR spine · 2026Article
- Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.Journal of clinical periodontology · 2026Article
- Biomechanical and cellular assessment of novel partially demineralized allogeneic bone plates: an ex-vivo and in-vitro study.International journal of implant dentistry · 2025Article
- Biofunctionalization of silk fibroin scaffolds with enamel matrix protein and injectable platelet rich fibrin for soft tissue augmentation: an in-ovo study.International journal of implant dentistry · 2025Article
- Histomorphometric and immunohistochemical assessment of treated dentin matrix delivered by platelet-rich fibrin for socket preservation in rabbit model.BMC oral health · 2025Article
- Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin.Clinical oral investigations · 2024Article
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate.Frontiers in bioengineering and biotechnology · 2024Article
- Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization.Frontiers in bioengineering and biotechnology · 2024Review
- Article
- Does platelet-rich fibrin increase bone regeneration in mandibular third molar extraction sockets?Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Article
- A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2022Review
- Effects of collagen membranes and bone substitute differ in periodontal ligament cell microtissues and monolayers.Journal of periodontology · 2022Article
- Biofunctionalization of Xenogeneic Collagen Membranes with Autologous Platelet Concentrate-Influence on Rehydration Protocol and Angiogenesis.Biomedicines · 2022Article
- Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw.Journal of clinical medicine · 2022Article
- From Blood to Bone-The Osteogenic Activity of L-PRF Membranes on the Ex Vivo Embryonic Chick Femur Development Model.Materials (Basel, Switzerland) · 2021Article
- The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro.Materials (Basel, Switzerland) · 2021Article
- Possible Implications for Improved Osteogenesis? The Combination of Platelet-Rich Fibrin With Different Bone Substitute Materials.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The impaired angiogenic potential of bone substitute materials (BSMs) may limit regenerative processes. Therefore, changes in the angiogenetic properties of different BSMs in combination with platelet-rich fibrin (PRF) in comparison to PRF alone, as well as to native BSMs, were analyzed in vitro and in vivo to evaluate possible clinical application. In vitro, four BSMs of different origins (allogeneic, alloplastic, and xenogeneic) were biofunctionalized with PRF and compared to PRF in terms of platelet interaction and growth factor release (vascular endothelial growth factor (VEGF), tissue growth factor ß (TGFß) and platelet-derived growth factor (PDGF)) after 15 min. To visualize initial cell-cell interactions, SEM was performed. In vivo, all BSMs (±PRF) were analyzed after 24 h for new-formed vessels using a chorioallantoic membrane (CAM) assay. Especially for alloplastic BSMs, the addition of PRF led to a significant consumption of platelets (
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