Evidence map›Paper›PMID 33435152›Full record

ArticleBrain sciences2021

Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives.

Giuseppe Roberto Giammalva, Cesare Gagliardo, Salvatore Marrone, Federica Paolini, Rosa Maria Gerardi, Giuseppe Emmanuele Umana, Kaan Yağmurlu, Bipin Chaurasia, Gianluca Scalia, Federico Midiri and 9 more

Abstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giuseppe Roberto GiammalvaNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Cesare GagliardoSection of Radiological Sciences, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0003-4088-2020
Salvatore MarroneNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Federica PaoliniNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-0865-045X
Rosa Maria GerardiNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Giuseppe Emmanuele UmanaDepartment of Neurosurgery, Cannizzaro Hospital, 95126 Catania, Italy.ORCID 0000-0002-1573-431X
Kaan YağmurluDepartments of Neuroscience and Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USA.ORCID 0000-0002-7635-2809
Bipin ChaurasiaDepartment of Neurosurgery, Neurosurgery Clinic, Birgunj 44300, Nepal.
Gianluca ScaliaDepartment of Neurosurgery, Highly Specialized Hospital of National Importance "Garibaldi", 95122 Catania, Italy.ORCID 0000-0002-9465-2506
Federico MidiriSection of Radiological Sciences, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Ludovico La GruttaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-ProMISE, University of Palermo, 90127 Palermo, Italy.
Luigi BasileNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Carlo GulìNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Domenico MessinaNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Maria Angela PinoNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Francesca GrazianoDepartment of Neurosurgery, Highly Specialized Hospital of National Importance "Garibaldi", 95122 Catania, Italy.
Silvana TumbioloDivision of Neurosurgery, Villa Sofia Hospital, 90146 Palermo, Italy.
Domenico Gerardo IacopinoNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Rosario MaugeriNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood-brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology.

Indexed as

blood-brain barrierepilepsyfocused ultrasoundHIFULIFUneurodegenerative diseasesneuro-oncologypsychiatric disorderstcMRgFUS

Identifiers

PMID33435152
PMCPMC7827488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.