Evidence map›Paper›PMID 33434830›Full record

ArticlePsychoneuroendocrinology2021

Optimism and telomere length among African American adults in the Jackson Heart Study.

Harold H Lee, Sakurako S Okuzono, Eric S Kim, Immaculata De Vivo, Laura M Raffield, LáShauntá Glover, Mario Sims, Francine Grodstein, Laura D Kubzansky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Harold H LeeDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA. Electronic address: hhlee@hsph.harvard.edu.
Sakurako S OkuzonoDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Eric S KimDepartment of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
Immaculata De VivoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Genetic Medicine Building, 120 Mason Farm Rd, Chapel Hill, NC 27514, USA.
LáShauntá GloverDepartment of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC 27599, USA.
Mario SimsDepartment of Medicine, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA.
Francine GrodsteinRush Alzheimer's Disease Center, 600 South Paulina Street, Suite 1028, Chicago, IL 60612, USA.
Laura D KubzanskyDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Harvard University · USUniversity of North Carolina at Chapel Hill · USRush University · USUniversity of British Columbia · CAUniversity of Mississippi Medical Center · US

Funding

The Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8M
Optimism and Exceptional LongevityR01AG053273 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRODSTEIN, FRANCINE, KUBZANSKY, LAURA D · 2016 to 2019
$2.2M
NHLBI NIH HHS HHSN268201800015INHLBI NIH HHS T32 HL129982NIA NIH HHS R01 AG053273NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

backgroundOptimism is linked with greater longevity in both White and African American populations. Optimism may enhance longevity by slowing cellular aging, for which leukocyte telomere shortening is a biomarker. However, limited studies have examined the association of optimism with leukocyte telomere length among African Americans.

methodsData are from 723 men and 1244 women participating in the Jackson Heart Study (age = 21-93 years). We used multivariable linear regression models to conduct cross-sectional analyses examining whether higher optimism was associated with longer mean absolute leukocyte telomere length (assayed with Southern blot analysis). Models adjusted for sociodemographic characteristics, depressive symptomatology, health conditions, and health behavior-related factors. We also considered potential effect modification by key factors.

resultsIn the age-adjusted model, optimism, measured as a continuous variable, was not associated with leukocyte telomere length (β = 0.01, 95%CI: -0.02, 0.04). This association remained null in the fully-adjusted model (β = 0.02, 95%CI: -0.02, 0.05) and was also null when considering optimism as a binary measure (higher vs. lower optimism). We found no evidence of effect modification by sex, age, body mass index, income, or chronic conditions.

conclusionsOptimism was not associated with leukocyte telomere length among African American adults. Future studies should investigate alternate biological and behavioral mechanisms that may explain the optimism-health association.

Indexed as

Black or African AmericanTelomereAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLeukocytesLongitudinal StudiesMaleMiddle AgedTelomere ShorteningYoung AdultHealth psychologyOptimismPsychological well-beingTelomere length

Identifiers

PMID33434830
PMCPMC8052931
OpenAlexW3115381220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.