Evidence map›Paper›PMID 33434615›Full record

ArticleAlcohol (Fayetteville, N.Y.)2021

Randomized controlled trials for alcohol use disorder during the COVID-19 pandemic.

Zoe E Brown, Samantha M Portis, Carline L Fleig, Talia Vasaturo-Kolodner, Robert M Swift, Carolina L Haass-Koffler

Open access · greenAbstract readEditorial
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zoe E BrownCenter for Alcohol and Addiction Studies, Brown University Providence, RI, United States.
Samantha M PortisCenter for Alcohol and Addiction Studies, Brown University Providence, RI, United States; Department of Behavioral and Social Sciences, School of Public Health, Brown University Providence, RI, United States.
Carline L FleigCenter for Alcohol and Addiction Studies, Brown University Providence, RI, United States.
Talia Vasaturo-KolodnerDepartment of Neuroscience, Brown University, Providence, RI, United States.
Robert M SwiftCenter for Alcohol and Addiction Studies, Brown University Providence, RI, United States; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United States; Veterans Administration Medical Center, Providence, RI, United States.
Carolina L Haass-KofflerCenter for Alcohol and Addiction Studies, Brown University Providence, RI, United States; Department of Behavioral and Social Sciences, School of Public Health, Brown University Providence, RI, United States; Department of Neuroscience, Brown University, Providence, RI, United States; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United States. Electronic address: carolina_haass-koffler@brown.edu.
Brown University · USUnited States Department of Veterans Affairs · US

Funding

Using wearables and EMA to examine the links between cannabis and depressionP20GM130414 · NIGMS · BROWN UNIVERSITY · PI Tyler Blake Wray · 2019 to 2026
$22.0M
ALCOHOL INTERVENTION/TREATMENT OUTCOME RESEARCH TRAININGT32AA007459 · NIAAA · BROWN UNIVERSITY · PI ROBERT MIRANDA, PETER M. MONTI · 1986 to 2026
$13.3M
A focus on alpha-1 blockade as a novel pharmacological treatment for alcohol use disorderR01AA027760 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2019 to 2023
$2.6M
Lead optimization of novel CRFBP-CRFR2 complex modulators for alcohol use disorderR01AA026589 · NIAAA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SHEFFLER, DOUGLAS J · 2019 to 2021
$2.4M
Mifepristone As A Pharmacological Intervention For Stress-Induced Alcohol DrinkingK01AA023867 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2016 to 2020
$901k
Probenecid as pharmacotherapy for alcohol use disorderR21AA027614 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2020 to 2021
$427k
NIAAA NIH HHS K01 AA023867NIAAA NIH HHS R01 AA026589NIAAA NIH HHS R01 AA027760NIAAA NIH HHS R21 AA027614NIAAA NIH HHS T32 AA007459NIGMS NIH HHS P20 GM130414
6 · The paper itself

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) altered the logistics of ongoing randomized controlled trials (RCTs). The need to reduce in-person research and clinical activities, however, presented an additional level of complexity in order to continue conducting RCTs that focused on the development of medications for Alcohol Use Disorder (AUD). The visits required a systematic objective evaluation from the physician and mental health professional and clinical staff, as many of the safety and efficacy assessments are self-reported. The following commentary addresses the successes and limitations our RCTs encountered during the coronavirus (COVID-19) pandemic.

Indexed as

AlcoholismCOVID-19Health Services AccessibilityHumansPatient SelectionRandomized Controlled Trials as TopicRemote ConsultationSelf ReportSubstance Withdrawal Syndrome

Identifiers

PMID33434615
PMCPMC7832637
OpenAlexW3120450080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.