Evidence map›Paper›PMID 33434353›Full record

ArticleBrain and behavior2021

Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke.

Yaqiong Chai, Chaoran Ji, Julie Coloigner, Soyoung Choi, Melissa Balderrama, Chau Vu, Benita Tamrazi, Thomas Coates, John C Wood, Sharon H O'Neil and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yaqiong ChaiCIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4175-6720
Chaoran JiCIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Julie ColoignerCIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7774-8015
Soyoung ChoiNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Melissa BalderramaDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chau VuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Benita TamraziDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Thomas CoatesDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John C WoodDivision of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Sharon H O'NeilDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Natasha LeporeCIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Neuromodulatory Mechanisms and Regional Autonomic Dysregulation in the Development of Pain in Sickle Cell Disease PatientsU01HL117718 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COATES, THOMAS DUANE, KHOO, MICHAEL C K · 2013 to 2017
$9.6M
Predicting the early childhood outcomes of preterm brain shape abnormalitiesR01EB025032 · NIBIB · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA · 2017 to 2020
$2.6M
Cerebrovascular reserve and white matter disease in patients with anemiaR01HL136484 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2018 to 2021
$2.5M
Neurological Consequences of AnemiaF31NS106828 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOI, SOYOUNG · 2018 to 2020
$116k
NCATS NIH HHS UL1 TR001855NHLBI NIH HHS R01 HL136484NHLBI NIH HHS U01 HL117718NIBIB NIH HHS R01 EB025032NINDS NIH HHS F31 NS106828
6 · The paper itself

Abstract

introductionSickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. SCD patients are at increased risks for strokes and neurocognitive deficit, even though neurovascular screening and treatments have lowered the rate of overt strokes. Tract-specific analysis (TSA) is a statistical method to evaluate microstructural WM damage in neurodegenerative disorders, using diffusion tensor imaging (DTI).

methodsWe utilized TSA and compared 11 major brain WM tracts between SCD patients with no history of overt stroke, anemic controls, and healthy controls. We additionally examined the relationship between the most commonly used DTI metric of WM tracts and neurocognitive performance in the SCD patients and healthy controls.

resultsDisruption of WM microstructure orientation-dependent metrics for the SCD patients was found in the genu of the corpus callosum (CC), cortico-spinal tract, inferior fronto-occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculus, and left uncinate fasciculus. Neurocognitive performance indicated slower processing speed and lower response inhibition skills in SCD patients compared to controls. TSA abnormalities in the CC were significantly associated with measures of processing speed, working memory, and executive functions.

conclusionDecreased DTI-derived metrics were observed on six tracts in chronically anemic patients, regardless of anemia subtype, while two tracks with decreased measures were unique to SCD patients. Patients with WMHs had more significant FA abnormalities. Decreased FA values in the CC significantly correlated with all nine neurocognitive tests, suggesting a critical importance for CC in core neurocognitive processes.

Indexed as

Anemia, Sickle CellStrokeWhite MatterCorpus CallosumDiffusion Tensor ImagingHumansmicrostructural damageneurocognitivesickle cell diseasetract-specific analysiswhite matter

Identifiers

PMID33434353
PMCPMC7994688
OpenAlexW3119060684

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.