Evidence map›Paper›PMID 33434347›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2021

Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth.

Samantha R Weaver, Earnest L Taylor, Elizabeth L Zars, Katherine M Arnold, Elizabeth W Bradley, Jennifer J Westendorf

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Samantha R Weaver *Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6034-214X
Earnest L Taylor *Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Elizabeth L ZarsDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Katherine M ArnoldDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Elizabeth W BradleyDepartment of Orthopedic Surgery and Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-8814-5524
Jennifer J WestendorfDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4464-6108
Mayo Clinic in Arizona · USZero to Three · USUniversity of Minnesota · US

Funding

DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Musculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0M
Protein Phosphatase Phlpp1 in Cartilage Development & Osteoarthritis ProgressionR01AR068103 · NIAMS · MAYO CLINIC ROCHESTER · PI WESTENDORF, JENNIFER J · 2014 to 2018
$1.9M
Functions of the PH-Domain Leucine Rich Protein Phosphatase (Phlpp)1 in OsteoclastsR01AR072634 · NIAMS · UNIVERSITY OF MINNESOTA · PI BRADLEY, ELIZABETH W · 2017 to 2021
$1.7M
Phlpp protein phosphatases in cartilage development and diseaseR56AR068103 · NIAMS · MAYO CLINIC ROCHESTER · PI WESTENDORF, JENNIFER J · 2019 to 2019
$552k
Epigenetic Regulation of Phlpp1 in Cartilage Development and RegenerationK01AR065397 · NIAMS · MAYO CLINIC ROCHESTER · PI BRADLEY, ELIZABETH W · 2014 to 2018
$440k
NIAMS NIH HHS K01 AR065397NIAMS NIH HHS R01 AR068103NIAMS NIH HHS R01 AR072634NIAMS NIH HHS R56 AR068103NIAMS NIH HHS T32 AR056950NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in the growth plate, longitudinal bone growth, and bone mineralization. As such, Phlpp1

Indexed as

Phosphoric Monoester HydrolasesReceptor, Parathyroid Hormone, Type 1AnimalsBlood ProteinsBone DevelopmentChondrocytesFibroblast Growth Factor-23LeucineMiceMice, KnockoutParathyroid HormonePhosphoprotein PhosphatasesPhosphoproteinsBlood ProteinsFgf23 protein, mouseFibroblast Growth Factor-23LeucineParathyroid HormonePHLPP1 protein, mousePhosphoprotein PhosphatasesPhosphoproteinsPhosphoric Monoester Hydrolasesplatelet protein P47PTH1R protein, mouseReceptor, Parathyroid Hormone, Type 1CHONDROCYTE AND CARTILAGE BIOLOGYGROWTH PLATEMOLECULAR PATHWAYS - DEVELOPMENTPTH/VIT D/FGF23

Identifiers

PMID33434347
PMCPMC8131217
OpenAlexW3120963245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.