Evidence map›Paper›PMID 33433956›Full record

ReviewAdvanced healthcare materials2021

Effects of Mesenchymal Stem Cell-Derived Paracrine Signals and Their Delivery Strategies.

Calvin Chang, Jerry Yan, Zhicheng Yao, Chi Zhang, Xiaowei Li, Hai-Quan Mao

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it, 221 citations in OpenAlex.

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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Calvin ChangDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-9755-8673
Jerry YanDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-8278-1354
Zhicheng YaoTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Chi ZhangTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0001-8201-3953
Xiaowei LiMary and Dick Holland Regenerative Medicine Program and Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0003-0714-1140
Hai-Quan MaoDepartment of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0002-4262-9988
Johns Hopkins University · USNebraska Medical Center · US

Funding

Promote Organization and Integration of Regenerated Neurons from Transplanted Human Neural Stem CellsR21NS096668 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2017 to 2018
$450k
NINDS NIH HHS R21 NS096668
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.

Indexed as

Extracellular VesiclesMesenchymal Stem CellsFibrosisHumansParacrine CommunicationWound Healingbiomaterialsextracellular vesiclesmesenchymal stem cellsmicroRNAparacrine signalingsecretome

Identifiers

PMID33433956
PMCPMC7995150
OpenAlexW3119998677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.