ArticleAngewandte Chemie (International ed. in English)2021
Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow*.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Chemputer and chemputation-A universal chemical compound synthesis machine.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in solid handling for continuous flow synthesis of specialty chemicals and pharmaceuticals.Communications chemistry · 2026Review
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Article
- Two-Step Synthesis of a Dolutegravir Intermediate DTG-6 in a Microfluidized Bed Cascade System: Route Design and Kinetic Study.Chem & bio engineering · 2025Article
- Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning.Beilstein journal of organic chemistry · 2025Review
- Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.Nature communications · 2024Article
- De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis.Nature communications · 2024Article
- Printed polymer platform empowering machine-assisted chemical synthesis in stacked droplets.Nature communications · 2024Article
- Simultaneous reaction- and analytical model building using dynamic flow experiments to accelerate process development.Chemical science · 2024Article
- Quantitative Online Monitoring of an Immobilized Enzymatic Network by Ion Mobility-Mass Spectrometry.Journal of the American Chemical Society · 2024Article
- Iterative Regression of Corrective Baselines (IRCB): A New Model for Quantitative Spectroscopy.Journal of chemical information and modeling · 2024Article
- Transaminase-catalysis to produce trans-4-substituted cyclohexane-1-amines including a key intermediate towards cariprazine.Communications chemistry · 2024Article
- A Slug Flow Platform with Multiple Process Analytics Facilitates Flexible Reaction Optimization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria.Frontiers in immunology · 2024Article
- An Automated Continuous Synthesis and Isolation for the Scalable Production of Aryl Sulfonyl Chlorides.Molecules (Basel, Switzerland) · 2023Article
- Process analytical technology as in-process control tool in semi-continuous manufacturing of PLGA/PEG-PLGA microspheres.Heliyon · 2023Article
- A field guide to flow chemistry for synthetic organic chemists.Chemical science · 2023Review
- Quid Pro Flow.Journal of the American Chemical Society · 2023Review
- Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self-Optimizing Flow Chemistry Platform.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In multistep continuous flow chemistry, studying complex reaction mixtures in real time is a significant challenge, but provides an opportunity to enhance reaction understanding and control. We report the integration of four complementary process analytical technology tools (NMR, UV/Vis, IR and UHPLC) in the multistep synthesis of an active pharmaceutical ingredient, mesalazine. This synthetic route exploits flow processing for nitration, high temperature hydrolysis and hydrogenation reactions, as well as three inline separations. Advanced data analysis models were developed (indirect hard modeling, deep learning and partial least squares regression), to quantify the desired products, intermediates and impurities in real time, at multiple points along the synthetic pathway. The capabilities of the system have been demonstrated by operating both steady state and dynamic experiments and represents a significant step forward in data-driven continuous flow synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.