Evidence map›Paper›PMID 33433867›Full record

ArticleAdvances in experimental medicine and biology2021

Nosology of Primary Progressive Aphasia and the Neuropathology of Language.

M -Marsel Mesulam, Christina Coventry, Eileen H Bigio, Changiz Geula, Cynthia Thompson, Borna Bonakdarpour, Tamar Gefen, Emily J Rogalski, Sandra Weintraub

Open access · greenAbstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
27.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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  12. Screening for Executive Impairment in Patients with Frontotemporal Dementia: Evidence from the Greek Version of the Frontier Executive Screen.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

M -Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Neurology, Northwestern University, Chicago, IL, USA. mmesulam@northwestern.edu.
Christina CoventryMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.
Eileen H BigioMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Pathology, Northwestern University, Chicago, IL, USA.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.
Cynthia ThompsonMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Communication Sciences and Disorders; Department of Neurology, Northwestern University, Evanston, IL, USA.
Borna BonakdarpourMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Neurology, Northwestern University, Chicago, IL, USA.
Tamar GefenMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Psychiatry, Northwestern University, Chicago, IL, USA.
Emily J RogalskiMesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Psychiatry, Northwestern University, Chicago, IL, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.
Northwestern University · USCenter for Neuro-Oncology · US

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MORHARDT, DARBY · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
Language in Primary Progressive AphasiaR01DC008552 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MESULAM, MAREK-MARSEL M · 2007 to 2021
$8.5M
Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical PhenotypeR01NS085770 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ · 2014 to 2024
$5.0M
Determinants of neurodegenerative decline in the aphasic variant of Alzheimer's diseaseR01AG056258 · NIA · UNIVERSITY OF CHICAGO · PI ROGALSKI, EMILY J · 2017 to 2022
$4.1M
Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard)R01AG062566 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEFEN, TAMAR D · 2020 to 2024
$2.1M
Determinants of Neurodegenerative Decline in Primary Progressive AphasiaR01NS075075 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROGALSKI, EMILY J · 2012 to 2016
$1.7M
Atrophy and resting state connectivity in primary progressive aphasiaK23DC014303 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONAKDARPOUR, BORNA · 2015 to 2019
$846k
NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG056258NIA NIH HHS R01 AG062566NIDCD NIH HHS K23 DC014303NIDCD NIH HHS R01 DC008552NINDS NIH HHS R01 NS075075NINDS NIH HHS R01 NS085770
6 · The paper itself

Abstract

Primary progressive aphasia (PPA) is a dementia syndrome associated with several neuropathologic entities, including Alzheimer's disease (AD) and all major forms of frontotemporal lobar degeneration (FTLD). It is classified into subtypes defined by the nature of the language domain that is most impaired. The asymmetric neurodegeneration of the hemisphere dominant for language (usually left) is one consistent feature of all PPA variants. This feature offers unique opportunities for exploring mechanisms of selective vulnerability in neurodegenerative diseases and the neuroanatomy of language. This chapter reviews some of the current trends in PPA research as well as the challenges that remain to be addressed on the nosology, clinicopathologic correlations, and therapy of this syndrome.

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveFrontotemporal DementiaFrontotemporal Lobar DegenerationHumansLanguageAlzheimerAsymmetryBrocaGrammarLanguageNamingSelective vulnerabilityWernickeWord comprehension

Identifiers

PMID33433867
PMCPMC8103786
OpenAlexW3119583722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.