Evidence map›Paper›PMID 33433856›Full record

ReviewPain and therapy2021

Interventional Radiofrequency Treatment for the Sympathetic Nervous System: A Review Article.

Nicholas A Zacharias, Jay Karri, Carol Garcia, Laura K Lachman, Alaa Abd-Elsayed

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Pain and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06204874 (Evaluation of Pulsed Radiofrequency Ablation of the Superior Hypogastric Plexus for Treatment of Bladder Pain Syndrome), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06204874 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Pulsed Radiofrequency Ablation of the Superior Hypogastric Plexus for Treatment of Bladder Pain Syndrome: A Case Series

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2024 to 2026Enrolled5ConditionsBladder Pain SyndromeArmsPulsed radiofrequency ablation
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025
    Review
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicholas A ZachariasDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jay KarriDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Carol GarciaDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Laura K LachmanDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. alaaawny@hotmail.com.
University of Wisconsin–Madison · USBaylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInterventional techniques such as radiofrequency (RF) treatment can be used to interrupt pain signals transmitted through the sympathetic nervous system (SNS). RF treatments including the pulsed (PRF) and continuous (CRF) modalities show enhanced control over lesion size and enhanced ability to confirm accurate positioning compared to other interventional methods. PRF also acts to reduce the area of the lesion. In this article, we characterize the currently available evidence supporting the use and efficacy of RF treatments in sympathetically mediated pain (SMP) conditions. STUDY

designA comprehensive literature review.

methodsA PubMed and Cochrane Library database search was performed for human studies applying RF treatment at sympathetic sites (sphenopalatine ganglion, stellate ganglion, cervical, thoracic, or lumbar sympathetic ganglia, celiac plexus, splanchnic nerves, superior hypogastric plexus, and ganglion impar) between January 1970 to May 2020. Data were extracted, summarized into tables, and qualitatively analyzed.

resultsPRF and CRF both show promise in relieving SMP conditions, such as complex regional pain syndrome (CRPS), pain in the perineal region, headache and facial pain, and oncologic and non-oncologic abdominal pain, in addition to other types of pain, with minimal complications. Furthermore, in most comparative studies, outcomes using RF treatments exceeded other interventional techniques, such as anesthetic block and chemical neurolysis.

conclusionsRF treatments can be effective in carefully selected patients who are refractory to conservative management. However, further randomized controlled studies are needed prior to implementing it into common practice.

Indexed as

Complex regional pain syndrome (CRPS)RadiofrequencySympathectomySympathetically mediated painSympathetic nervous system

Identifiers

PMID33433856
PMCPMC8119558
OpenAlexW3118368148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.