Evidence map›Paper›PMID 33433815›Full record

Observational studyDigestive diseases and sciences2021

Long-Term Dietary Changes in Subjects with Glucose Galactose Malabsorption Secondary to Biallelic Mutations of SLC5A1.

Alvin P Chan, Shweta S Namjoshi, Patricia M Jardack, Lisa Maloney, Atrin Ardjmand, Nicholas N Jackson, Martin G Martin

Open access · hybridAbstract readCase ReportsObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Renal glucosuria in children.World journal of clinical pediatrics · 2025
    Review
  2. Article
  3. Review
  4. Diet and Management of Diarrhea.Indian journal of pediatrics · 2024
    Review
  5. Novel Mutation in theJPGN reports · 2023
    Article
  6. Genes · 2023
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alvin P ChanDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Mattel Children's Hospital and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. alvinchan@mednet.ucla.edu.ORCID 0000-0002-7413-8745
Shweta S NamjoshiDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lucile Packard Children's Hospital and Stanford University School of Medicine, Stanford University, Palo Alto, CA, 94304, USA.
Patricia M JardackClinical Translational Research Center, Clinical and Translational Science Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Lisa MaloneyFood Science Solutions, San Diego, CA, 92101, USA.
Atrin ArdjmandDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Nicholas N JacksonDepartment of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Martin G MartinDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Mattel Children's Hospital and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USLucile Packard Children's Hospital · USScience Education Solutions (United States) · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Neurogenin3 and Intestinal FailureR01DK083762 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2009 to 2012
$1.6M
Cell Fate Determination of the Intestine and Chronic Diarrhea in ChildrenR21DK075009 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2006 to 2007
$305k
NCATS NIH HHS UL1 TR001881NIDDK NIH HHS R01 DK083762NIDDK NIH HHS R21 DK075009NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

backgroundGlucose galactose malabsorption (GGM) is a congenital diarrheal disorder of intestinal Na+/glucose cotransport (SGLT1/SLC5A1). The required glucose and galactose-restricted diet has been well described in infancy, but long-term nutrition follow-up is limited.

aimTo perform a comprehensive nutritional assessment on a cohort of patients with GGM to gain insights into the consumption patterns within the population.

methodsA cross-sectional study examining dietary intake of a GGM cohort using prospective food records. The calories and nutrients of all foods, beverages, and condiments were analyzed with descriptive statistics and compared to intake patterns of age- and sex-matched NHANES groups.

resultsThe six patients were 0.7-26 years old. Whole foods and vegetable fats were major parts of the diet, while dairy and added sweeteners were restricted. Compared to typical US intakes, mean macronutrient distribution was 88th percentile from fat, 18th percentile from carbohydrates, and 78th percentile from protein. Fructose consumption, as a proportion of total sugar intake, decreased with age, from 86.1 to 50.4%. Meanwhile, glucose consumption increased with age, from 13.8 to 48.6% of sugar intake. However, the actual amount of glucose consumed remained low, equivalent to 4th percentile of US consumption level. Galactose intake was marginal throughout life.

conclusionsA GGM diet is a high-fat and high-protein/low-carbohydrate diet that is rich in fruits and vegetables but limited in dairy and added sugar. Relatively less fructose but more glucose is incorporated into the diet with age. Future studies should investigate the effects of the GGM diet on gut microbiome and long-term health.

Indexed as

AdultCarbohydrate Metabolism, Inborn ErrorsChildChild, PreschoolCohort StudiesCross-Sectional StudiesDietFemaleHumansInfantMalabsorption SyndromesMaleSodium-Glucose Transporter 1SLC5A1 protein, humanSodium-Glucose Transporter 1DietGlucose galactose malabsorptionHigh fatLow carbohydrateNutritionSLC5A1Sodium/glucose cotransporter

Identifiers

PMID33433815
PMCPMC8273183
OpenAlexW3119372553

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.