Evidence map›Paper›PMID 33433814›Full record

ArticleDigestive diseases and sciences2021

Recurrence of Clostridium Difficile and Cytomegalovirus Infections in Patients with Ulcerative Colitis Who Undergo Ileal Pouch-Anal Anastomosis.

Jonathan Pastrana Del Valle, Grace C Lee, Jose Cataneo Serrato, Joseph D Feuerstein, Liliana Grigorievna Bordeianou, Richard Hodin, Hiroko Kunitake, Vitaliy Poylin

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Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jonathan Pastrana Del ValleDepartment of Surgery, Beth Israel Deaconess Medical Center, Beth Israel Deaconess Medical Center Suite 9B, 110 Francis Street, Boston, MA, 02215, USA.
Grace C LeeDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Jose Cataneo SerratoDepartment of Surgery, Beth Israel Deaconess Medical Center, Beth Israel Deaconess Medical Center Suite 9B, 110 Francis Street, Boston, MA, 02215, USA.
Joseph D FeuersteinDivision of Gastroenterology, Beth Israel Deaconess Medical Center Medicine, 330 Brookline Ave, Boston, MA, 02215, USA.
Liliana Grigorievna BordeianouDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Richard HodinDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Hiroko KunitakeHarvard Medical School, Boston, MA, USA.
Vitaliy PoylinDivision of Gastrointestinal and Oncologic Surgery, Northwestern Medicine, Arkes Family Pavilion, 676 North Saint Clair Street, Suite 650, Chicago, IL, 60611, USA. vitaliy.poylin2@nm.org.
Massachusetts General Hospital · USHarvard University · USNorthwestern Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with ulcerative colitis (UC) are at increased risk for infections such as Clostridium difficile and cytomegalovirus (CMV) colitis due to chronic immunosuppression. These patients often undergo multiple surgeries putting them at risk for recurrence of the infection. However, rates of recurrence in this setting and outcomes are not well understood.

aimThe aim of this study is to determine rates of recurrence of C difficile and CMV infection in patients undergoing multistage UC surgeries and effects of antibiotic prophylaxis on outcomes.

methodsAll patients with UC who underwent IPAA between 2001 and 2017 (at two tertiary referral centers were identified. History of C. difficile or CMV colitis prior to any surgery and recurrence after IPAA was noted

resultsA total of 633 patients with UC who underwent IPAA were identified, of whom 8.1% patients had C. difficile and 2.7% had CMV infections. 9.8% of C. difficile and 5.9% of CMV patients recurred after IPAA. Rates of abdominal sepsis (14.7% vs. 12.7%), 90-day mortality (0% vs. 0.4%), pouchitis (36.8% vs. 45.0%), or return to stoma (7.4% vs. 5.4%) were similar between patients who did or did not have infections. In patients with C. difficile infection prior to first surgery, none of the patients who received prophylaxis had recurrent infection.

conclusionsRates of C. difficile and CMV infections remain high in patients undergoing surgery for UC, with substantial minority developing recurrent infection during subsequent surgical procedures. Antibiotic prophylaxis in patients with a history of C difficile may reduce the rate of recurrent infection.

Indexed as

Proctocolectomy, RestorativeAdultClostridioides difficileColitis, UlcerativeCytomegalovirusCytomegalovirus InfectionsEnterocolitis, PseudomembranousFemaleHumansMaleMassachusettsPostoperative ComplicationsRecurrenceRetrospective StudiesClostridium difficileIleal pouch anal anastomosisUlcerative colitis

Identifiers

PMID33433814
OpenAlexW3121053688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.