ArticleDigestive diseases and sciences2021
Differential Cytokine Expression in the Duodenum and Rectum of Children with Non-Immunoglobulin E-Mediated Cow's Milk Protein Allergy.
Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Immunoblotting Analysis of Fruit Proteins in Mexican Pediatric Patients Suggests the Existence of New Allergens.Diseases (Basel, Switzerland) · 2025Article
- [Effect of interleukinZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Designing a Minimum Dataset for the Cow's Milk Protein Allergy in Children: Identifying and Evaluating the Key Factors in Managing, Controlling and Monitoring the Cow's Milk Protein Allergy in Children: A Cross-Sectional Study.Health science reports · 2025Article
- Differential expression of TOB/BTG family members in patients with plaque psoriasis: cross-sectional study.Immunologic research · 2024Observational
- Cow's Milk: A Benefit for Human Health? Omics Tools and Precision Nutrition for Lactose Intolerance Management.Nutrients · 2024Review
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundCow's milk protein allergy (CMPA) is the most prevalent food allergy in children, and its pathogenesis remains poorly understood. It has been shown that the combination of genetic predisposition, perinatal factors, and intestinal imbalance of the immune response mediated by cytokines may play an essential role in CMPA pathogenesis.
aimTo characterize the gene expression of Th1, Th2, and Th17 cytokines in the duodenum and rectum in patients with CMPA.
methodsThis is an observational, descriptive, cross-sectional, prospective study. We used specific IgE (ImmunoCAP
resultsThirty children (13 male and 17 female) were evaluated. All patients had an open challenge for CMPA. IgE specific to casein, alfa-lactalbumin, and beta-lactoglobulin was negative in all patients. In terms of cytokine levels, the levels of TNFα, IL-6, IL-12 (Th1), IL-4, IL-10, IL-13 (Th2), and IL-17 were found to be higher in the rectum than in the duodenum (p < 0.05). IL-15 was found to be higher in the duodenum than in the rectum (p < 0.05).
conclusionsIn the present study we observed that the immune response in CMPA seems to be mediated by a Th1, Th2, and Th17 cytokine profile, with the rectum being the main affected site.
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