Evidence map›Paper›PMID 33433752›Full record

ArticleInternational journal of clinical oncology2021

A retrospective assessment of the safety and efficacy of laparoscopic radical hysterectomy in Japan during the early years following its introduction: a Japanese Gynecologic Oncology Group study (JGOG1081S).

Eiji Kobayashi, Hiroyuki Kanao, Munetaka Takekuma, Shin Nishio, Atsumi Kojima-Chiba, Akiko Tozawa, Satoshi Yamaguchi, Nobuhiro Takeshima, Eiji Nakatani, Mikio Mikami

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Article in International journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Eiji KobayashiDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. ekobayashi@gyne.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-2314-5857
Hiroyuki KanaoDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo, Japan.
Munetaka TakekumaThe Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
Shin NishioDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.
Atsumi Kojima-ChibaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Iwate Medical University, Morioka, Japan.
Akiko TozawaDepartment of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
Satoshi YamaguchiDepartment of Gynecologic Oncology, Hyogo Cancer Center, Hyogo, Japan.
Nobuhiro TakeshimaDepartment of Gynecologic Oncology, Cancer Institute Hospital, Tokyo, Japan.
Eiji NakataniDivision of Statistical Analysis of Research Support Center, Shizuoka General Hospital, Shizuoka, Japan.
Mikio MikamiDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
The Cancer Institute Hospital · JPHyogo Prefectural Cancer Center · JPIwate Medical University · JPKurume University · JPShizuoka Cancer Center · JPShizuoka General Hospital · JPSt. Marianna University School of Medicine · JPThe University of Osaka · JPTokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety and efficacy of laparoscopic radical hysterectomy (LRH) for cervical cancer, in terms of morbidity and short-term oncologic outcome following LRH's introduction into Japan.

methodsWe conducted a retrospective analysis of patients with early-stage cervical cancer (FIGO staging IA2, IB1, and IIA1) who underwent LRH from Dec 2014 to Dec 2016. We assessed the morbidity, overall survival (OS) and recurrence-free survival (RFS), and prognostic factors for RFS.

resultsA total of 251 patients were included from 22 facilities across Japan. There were 8 cases of stage IA2 cervical cancer, 226 of IB1, and 17 of IIA1. The median operating time was 343 min and the median blood loss was 190 ml. Two patients (0.8%) had a postoperative complication with a Clavien-Dindo classification of grade 3 or higher. After a median follow-up time of 15.6 months, the 2-year RFS was 87.4%, and the 2-year OS was 97.8%. When the 2-year RFS rate was compared with whether the patient pathologically had tumors of less than 2 cm, versus 2 cm or more, the RFS was 95.8% and 80.4%, respectively. Multivariate analysis found that tumor size and the route of lymph node removal were independent prognostic factors for recurrence.

conclusionWhen LRH was first introduced into Japan, we found that the route of lymph node removal was an independent prognostic factor for recurrence in addition to large tumors (≥ 2 cm). Our results suggest that prognosis may be secured by paying attention to the lymph node removal route.

Indexed as

HysterectomyUterine Cervical NeoplasmsFemaleHumansJapanLaparoscopyLymph Node ExcisionNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesTreatment OutcomeCervical cancerLaparoscopicMinimally invasive surgeryPredictive factorPrognosis

Identifiers

PMID33433752
OpenAlexW3120992454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.