Evidence map›Paper›PMID 33433699›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres.

Hugo Levillain, Oreste Bagni, Christophe M Deroose, Arnaud Dieudonné, Silvano Gnesin, Oliver S Grosser, S Cheenu Kappadath, Andrew Kennedy, Nima Kokabi, David M Liu and 13 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06178198 (An Open-label, Single-arm, Single-center Clinical Trial to Evaluate the Efficacy and Safety of Yttrium-90 Ablative Radioembolization), which is not on this map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06178198 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

An Open-label, Single-arm, Single-center Clinical Trial to Evaluate the Efficacy and Safety of Yttrium-90 Ablative Radioembolization (Radiation Major Hepatectomy) for Unifocal Large Hepatocellular Carcinoma

TypeinterventionalSponsorSeoul National University HospitalRan2023 to 2026Enrolled30ConditionsHepatocellular CarcinomaArmsAblative radioembolization using Yttrium-90 resin microspheres
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it, 239 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Safety and Efficacy ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Trial
  5. Article
  6. Effects of dose heterogeneity on response and toxicity afterEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Comparison of pre-therapeutic [European journal of nuclear medicine and molecular imaging · 2026
    Article
  15. Advanced healthcare materials · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 18 institutions in 10 countries.

Hugo LevillainDepartment of Nuclear Medicine, Jules Bordet Institute, Université Libre de Bruxelles, Rue Héger-Bordet 1, B-1000, Brussels, Belgium. hugo.levillain@bordet.be.ORCID https://orcid.org/0000-0003-3909-625X
Oreste BagniNuclear Medicine Unit, Santa Maria Goretti Hospital, Latina, Italy.ORCID https://orcid.org/0000-0001-5084-4816
Christophe M DerooseNuclear Medicine, University Hospitals Leuven and Nuclear Medicine & Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-6080-1577
Arnaud DieudonnéDepartment of Nuclear Medicine, Hôpital Beaujon, AP-HP.Nord, DMU DREAM and Inserm U1149, Clichy, France.ORCID https://orcid.org/0000-0003-2825-2085
Silvano GnesinInstitute of Radiation Physics, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-6547-3824
Oliver S GrosserDepartment of Radiology and Nuclear Medicine, University Hospital Magdeburg, Germany and Research Campus STIMULATE, Otto-von-Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0002-0826-0734
S Cheenu KappadathDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID https://orcid.org/0000-0003-4643-7745
Andrew KennedySarah Cannon Research Institute, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-9761-2262
Nima KokabiDivision of Interventional Radiology and Image Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0002-4569-2720
David M LiuDepartment of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-5891-3609
David C MadoffDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-3461-437X
Armeen MahvashDepartment of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID https://orcid.org/0000-0003-0416-4566
Antonio Martinez de la CuestaClinica Universidad de Navarra-IDISNA and CIBEREHD, Pamplona, Spain.ORCID https://orcid.org/0000-0003-4869-1974
David C E NgDepartment of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore.ORCID https://orcid.org/0000-0001-8554-3036
Philipp M PaprottkaDepartment of Interventional Radiology, Technical University Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-5047-4659
Cinzia PettinatoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID https://orcid.org/0000-0003-2455-481X
Macarena Rodríguez-FraileClinica Universidad de Navarra-IDISNA and CIBEREHD, Pamplona, Spain.ORCID https://orcid.org/0000-0002-9069-7918
Riad SalemDepartment of Radiology, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-9745-1825
Bruno SangroClinica Universidad de Navarra-IDISNA and CIBEREHD, Pamplona, Spain.ORCID https://orcid.org/0000-0002-4177-6417
Lidia StrigariDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0003-4293-2298
Daniel Y SzeDepartment of Interventional Radiology, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID https://orcid.org/0000-0002-6885-0752
Berlinda J de Wit van der VeenDepartment of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-7860-2904
Patrick FlamenDepartment of Nuclear Medicine, Jules Bordet Institute, Université Libre de Bruxelles, Rue Héger-Bordet 1, B-1000, Brussels, Belgium.ORCID https://orcid.org/0000-0003-2193-6599
Centro de Investigación Biomédica en Red · ESThe University of Texas MD Anderson Cancer Center · USUniversité Libre de Bruxelles · BEAzienda USL di Bologna · ITEmory University · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITInserm · FRKU Leuven · BENorthwestern University · USOspedale Santa Maria Goretti · ITSarah Cannon · USSingapore General Hospital · SGStanford University · USThe Netherlands Cancer Institute · NLUniversity Hospital Magdeburg · DEUniversity of British Columbia · CAUniversity of Lausanne · CHYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

purposeA multidisciplinary expert panel convened to formulate state-of-the-art recommendations for optimisation of selective internal radiation therapy (SIRT) with yttrium-90 (

methodsA steering committee of 23 international experts representing all participating specialties formulated recommendations for SIRT with

resultsForty-seven recommendations were established, including guidance such as a multidisciplinary team should define treatment strategy and therapeutic intent (strong agreement); 3D imaging with CT and an angiography with cone-beam-CT, if available, and

conclusionPractitioners are encouraged to work towards adoption of these recommendations.

Indexed as

Embolization, TherapeuticLiver NeoplasmsHumansMicrospheresPositron Emission Tomography Computed TomographyTechnetium Tc 99m Aggregated AlbuminYttrium RadioisotopesTechnetium Tc 99m Aggregated AlbuminYttrium-90Yttrium RadioisotopesDosimetryLiver tumoursRecommendationsSIRT

Identifiers

PMID33433699
PMCPMC8113219
OpenAlexW3118964091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.