Evidence map›Paper›PMID 33433653›Full record

ArticleClinical oral investigations2021

Influence of different carrier materials on biphasic calcium phosphate induced bone regeneration.

Lara Schorn, Tim Fienitz, Maximilian F Gerstenberg, Anja Sterner-Kock, Alexandra C Maul, Julian Lommen, Henrik Holtmann, Daniel Rothamel

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lara SchornDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.
Tim FienitzDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Ludwig-Weber-Straße 15, 41061, Mönchengladbach, Germany. Tim.Fienitz@mg.johanniter-kliniken.de.ORCID http://orcid.org/0000-0001-7713-4902
Maximilian F GerstenbergDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, University Hospital of Cologne, Kerpener Str. 64, 50937, Cologne, Germany.
Anja Sterner-KockCenter for Experimental Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 64, 50937, Cologne, Germany.
Alexandra C MaulCenter for Experimental Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 64, 50937, Cologne, Germany.
Julian LommenDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.
Henrik HoltmannDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, Evangelisches Krankenhaus Bethesda, Ludwig-Weber-Straße 15, 41061, Mönchengladbach, Germany.
Daniel RothamelDepartment of Oral-, Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, Germany.
Düsseldorf University Hospital · DEEvangelisches Krankenhaus Bethesda Mönchengladbach · DEUniversity of Cologne · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesBiphasic calcium phosphate (BCP) is a bioceramic material successfully used in alloplastic bone augmentation. Despite many advantages, a disadvantage of BCP seems to be a difficult application and position instability. The aim of this study was to determine how different carrier materials influence BCP-induced quantitative and qualitative bone regeneration. MATERIALS AND

methodsA total of 70 critical size defects were set in the frontal bone of 14 domestic pigs (5 each) and filled randomly with either BCP alone (BCP), BCP in combination with nano-hydroxyapatite (BCP + NHA), BCP embedded in native porcine type I/III collagen blocks (BCP + C), autologous bone (AB), or were left empty (ED). Specimens were harvested after 4 and 8 weeks and were evaluated histologically as well as histomorphometrically.

resultsSignificantly lowest rate of new bone formation was found in ED (p = < 0.001) and BCP + NHA groups (p = 0.05). After 8 weeks, the highest percentage of new bone formation was observed in the BCP + C group. Fibrous matrix was detected highest in BCP alone. The lowest residual bone substitute material was found in BCP + C after 8 weeks.

conclusionsBCP-induced bone regeneration is indeed affected by different carrier types. Surface morphology and bioactive characteristics influence osseointegration and new bone formation in vivo. The combination of type I/III collagen seems most suitable for qualitative and quantitative bone regeneration. CLINICAL RELEVANCE: Stabilization of granular bone substitutes using type I/III collagen might be an alternative to granulates alone, indicating excellent volume stability, satisfactory plasticity, and easy application.

Indexed as

Bone SubstitutesHydroxyapatitesAnimalsBone RegenerationDurapatiteOsteogenesisSwineBone SubstitutesDurapatitehydroxyapatite-beta tricalcium phosphateHydroxyapatitesBiphasic calcium phosphateBone augmentationBone substitute materialCritical size defectsNano-hydroxyapatiteType I/III collagen

Identifiers

PMID33433653
OpenAlexW3120429402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.