Evidence map›Paper›PMID 33433395›Full record

ArticleJournal of medical Internet research2021

Use of BERT (Bidirectional Encoder Representations from Transformers)-Based Deep Learning Method for Extracting Evidences in Chinese Radiology Reports: Development of a Computer-Aided Liver Cancer Diagnosis Framework.

Honglei Liu, Zhiqiang Zhang, Yan Xu, Ni Wang, Yanqun Huang, Zhenghan Yang, Rui Jiang, Hui Chen

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Article in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

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26citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Knowledge-Informed Machine Learning for Cancer Diagnosis and Prognosis: A Review.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2025
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Honglei LiuSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0001-5518-4749
Zhiqiang ZhangSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0002-6848-4019
Yan XuDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-2795-0984
Ni WangSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0002-8941-0457
Yanqun HuangSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0001-8111-6352
Zhenghan YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-6993-7614
Rui JiangMinistry of Education Key Laboratory of Bioinformatics, Research Department of Bioinformatics at the Beijing National Research Center for Information Science and Technology, Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing, China.ORCID 0000-0002-7533-3753
Hui ChenSchool of Biomedical Engineering, Capital Medical University, Beijing, China.ORCID 0000-0002-0048-0193

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver cancer is a substantial disease burden in China. As one of the primary diagnostic tools for detecting liver cancer, dynamic contrast-enhanced computed tomography provides detailed evidences for diagnosis that are recorded in free-text radiology reports.

objectiveThe aim of our study was to apply a deep learning model and rule-based natural language processing (NLP) method to identify evidences for liver cancer diagnosis automatically.

methodsWe proposed a pretrained, fine-tuned BERT (Bidirectional Encoder Representations from Transformers)-based BiLSTM-CRF (Bidirectional Long Short-Term Memory-Conditional Random Field) model to recognize the phrases of APHE (hyperintense enhancement in the arterial phase) and PDPH (hypointense in the portal and delayed phases). To identify more essential diagnostic evidences, we used the traditional rule-based NLP methods for the extraction of radiological features. APHE, PDPH, and other extracted radiological features were used to design a computer-aided liver cancer diagnosis framework by random forest.

resultsThe BERT-BiLSTM-CRF predicted the phrases of APHE and PDPH with an F1 score of 98.40% and 90.67%, respectively. The prediction model using combined features had a higher performance (F1 score, 88.55%) than those using APHE and PDPH (84.88%) or other extracted radiological features (83.52%). APHE and PDPH were the top 2 essential features for liver cancer diagnosis.

conclusionsThis work was a comprehensive NLP study, wherein we identified evidences for the diagnosis of liver cancer from Chinese radiology reports, considering both clinical knowledge and radiology findings. The BERT-based deep learning method for the extraction of diagnostic evidence achieved state-of-the-art performance. The high performance proves the feasibility of the BERT-BiLSTM-CRF model in information extraction from Chinese radiology reports. The findings of our study suggest that the deep learning-based method for automatically identifying evidences for diagnosis can be extended to other types of Chinese clinical texts.

Indexed as

Natural Language ProcessingChinaDeep LearningDiagnosis, Computer-AssistedHumansInformation Storage and RetrievalLiver NeoplasmsRadiologyBERTBiLSTM-CRFcomputer-aided diagnosisinformation extractionnatural language processingradiology reports

Identifiers

PMID33433395
PMCPMC7837998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.