Evidence map›Paper›PMID 33433069›Full record

ArticleJournal of thrombosis and haemostasis : JTH2020

Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH.

Tzu-Fei Wang, Robert S Makar, Darko Antic, Jerrold H Levy, James D Douketis, Jean M Connors, Marc Carrier, Jeffrey I Zwicker

Open access · bronzeAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Emergency anticancer therapy in intensive care medicine: A mainland China survey.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Emergencies in Hematology: Why, When and How I Treat?Journal of clinical medicine · 2024
    Review
  15. Review
  16. Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia.Mediterranean journal of hematology and infectious diseases · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Tzu-Fei WangDepartment of Medicine, University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0003-2407-9000
Robert S MakarBlood Transfusion Service, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Darko AnticClinic for Hematology, Clinical Center Serbia, Belgrade, Serbia.
Jerrold H LevyDepartments of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
James D DouketisDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0001-5288-0394
Jean M ConnorsDivision of Hematology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-6445-582X
Marc CarrierDepartment of Medicine, University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jeffrey I ZwickerDivision of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5810-6893
University of Ottawa · CABeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USDuke University · USHarvard University · USMcMaster University · CAUniversity of Belgrade · RS

Funding

Biomarkers and mechanisms in cancer associated thrombosisU01HL143365 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, FLAUMENHAFT, ROBERT C · 2018 to 2022
$4.3M
NHLBI NIH HHS U01 HL143365
6 · The paper itself

Abstract

Patients with acute leukemia frequently develop thrombocytopenia and hemostatic complications caused by coagulopathy. Coagulopathy complicates the management of these patients and can lead to significant morbidity and mortality. This guidance document aims to review and provide guidance on the management of hemostatic complications in adult patients with acute leukemia, addressing four main issues, including platelet transfusion, disseminated intravascular coagulation, L-asparaginase-related hypofibrinogenemia, and the use of antifibrinolytic agents.

Indexed as

Antifibrinolytic AgentsDisseminated Intravascular CoagulationHemostaticsLeukemia, Myeloid, AcuteAcute DiseaseAdultHumansAntifibrinolytic AgentsHemostaticsacute leukemiaguidancehemostatic complications

Identifiers

PMID33433069
PMCPMC7909744
OpenAlexW3110450048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.