Evidence map›Paper›PMID 33433017›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2021

LRRK2 Loss-of-Function Variants in Patients with Rare Diseases: No Evidence for a Phenotypic Impact.

Christian Beetz, Ana Westenberger, Ruslan Al-Ali, Najim Ameziane, Nadia Alhashmi, Rose-Mary Boustany, Fuad Al Mutairi, Majid Alfadhel, Zuhair Al-Hassnan, Moenaldeen AlSayed and 5 more

Open access · hybridAbstract readLetter
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Christian BeetzCENTOGENE GmbH, Rostock, Germany.ORCID 0000-0001-7061-2895
Ana WestenbergerCENTOGENE GmbH, Rostock, Germany.ORCID 0000-0001-8062-6959
Ruslan Al-AliCENTOGENE GmbH, Rostock, Germany.
Najim AmezianeCENTOGENE GmbH, Rostock, Germany.
Nadia AlhashmiNational Genetic Center, Royal Hospital, Muscat, Oman.
Rose-Mary BoustanyNeurogenetics Program, AUBMC Special Kids Clinic and Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Fuad Al MutairiGenetics and Precision Medicine Department, King Abdullah Specialist Children Hospital, King Abdulaziz Medical City, MNGHA, Riyadh, Saudi Arabia.
Majid AlfadhelGenetics and Precision Medicine Department, King Abdullah Specialist Children Hospital, King Abdulaziz Medical City, MNGHA, Riyadh, Saudi Arabia.
Zuhair Al-HassnanDepartment of Medical Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Moenaldeen AlSayedDepartment of Medical Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Krishna K KandaswamyCENTOGENE GmbH, Rostock, Germany.
Omid PakniaCENTOGENE GmbH, Rostock, Germany.
Volha SkrahinaCENTOGENE GmbH, Rostock, Germany.
Arndt RolfsCENTOGENE GmbH, Rostock, Germany.
Peter BauerCENTOGENE GmbH, Rostock, Germany.ORCID 0000-0001-9414-4555
Centogene (Germany) · DEAlfaisal University · SAKing Saud bin Abdulaziz University for Health Sciences · SAAmerican University of Beirut Medical Center · LBRoyal Hospital · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Protein Serine-Threonine KinasesRare DiseasesHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Leucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanProtein Serine-Threonine Kinases

Identifiers

PMID33433017
PMCPMC8248088
OpenAlexW3119609945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.