Evidence map›Paper›PMID 33432845›Full record

ArticleJournal of the American Heart Association2021

Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness.

Christoffer Polcwiartek, Brett D Atwater, Kristian Kragholm, Daniel J Friedman, Carlo A Barcella, Rubina Attar, Claus Graff, Jonas B Nielsen, Adrian Pietersen, Peter Søgaard and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Coronary Artery Disease in Patients with Severe Mental Illness.Interventional cardiology (London, England) · 2023
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Christoffer PolcwiartekDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Brett D AtwaterDivision of Cardiology Duke University Medical Center Durham NC.
Kristian KragholmDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Daniel J FriedmanSection of Cardiac Electrophysiology Yale School of Medicine New Haven CT.
Carlo A BarcellaDepartment of Cardiology Copenhagen University Hospital Gentofte Hellerup Denmark.
Rubina AttarDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Claus GraffDepartment of Health Science and Technology Aalborg University Aalborg Denmark.
Jonas B NielsenLaboratory for Molecular Cardiology The Heart CenterCopenhagen University HospitalRigshospitalet Copenhagen Denmark.
Adrian PietersenCopenhagen General Practitioners' Laboratory Copenhagen Denmark.
Peter SøgaardDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Christian Torp-PedersenDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Svend E JensenDepartment of Cardiology Aalborg University Hospital Aalborg Denmark.
Aalborg University Hospital · DKAalborg University · DKCopenhagen University Hospital · DKDanish College of General Practitioners · DKDuke Medical Center · USGentofte Hospital · DKLund University · SEYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background ECG abnormalities are associated with adverse outcomes in the general population, but their prognostic significance in severe mental illness (SMI) remains unexplored. We investigated associations between no, minor, and major ECG abnormalities and fatal cardiovascular disease (CVD) among patients with SMI compared with controls without mental illness. Methods and Results We cross-linked data from Danish nationwide registries and included primary care patients with digital ECGs from 2001 to 2015. Patients had SMI if they were diagnosed with schizophrenia, bipolar disorder, or severe depression before ECG recording. Controls were required to be without any prior mental illness or psychotropic medication use. Fatal CVD was assessed using hazard ratios (HRs) with 95% CIs and standardized 10-year absolute risks. Of 346 552 patients, 10 028 had SMI (3%; median age, 54 years; male, 45%), and 336 524 were controls (97%; median age, 56 years; male, 48%). We observed an interaction between SMI and ECG abnormalities on fatal CVD (

Indexed as

Cardiovascular DiseasesElectrocardiographyMental DisordersComorbidityDenmarkFemaleHumansMaleMiddle AgedPredictive Value of TestsPrimary Health CarePrognosisRegistriesRisk AssessmentRisk FactorsVulnerable PopulationsECGprimary carerisk predictionsevere mental illness

Identifiers

PMID33432845
PMCPMC7955293
OpenAlexW3119076090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.