Evidence map›Paper›PMID 33432826›Full record

ArticleCell transplantation

Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats.

Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Xenia Kaidonis, Karlea L Kremer, Fong Chan Choy, Richard J Woodman, Simon A Koblar, Neil R Sims

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wai Ping YewCentre for Neuroscience, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0001-7436-0779
Natalia D DjukicCentre for Neuroscience, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Jaya S P JayaseelanCentre for Neuroscience, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Xenia KaidonisStroke Research Programme, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Karlea L KremerStroke Research Programme, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Fong Chan ChoyStroke Research Programme, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Richard J WoodmanFlinders Centre for Epidemiology and Biostatistics, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Simon A KoblarStroke Research Programme, School of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Neil R SimsCentre for Neuroscience, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0003-1830-091X
Flinders University · AUSouth Australian Health and Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats. To further assess the therapeutic potential of these cells, we tested whether functional recovery following stroke induced by photothrombosis could be modified by a delayed treatment that was initiated after the infarct attained maximal volume. Photothrombosis induces permanent focal ischemia resulting in tissue changes that better reflect key aspects of the many human strokes in which early restoration of blood flow does not occur. Human dental pulp stem cells (approximately 400 × 10

Indexed as

AnimalsAstrocytesDental PulpDisease Models, AnimalHumansMaleRatsRats, Sprague-DawleyRecovery of FunctionStem CellsStem Cell TransplantationStrokeastrocytesdental pulp stem cellsfocal ischemiafunctional recoveryperi-infarctstroke

Identifiers

PMID33432826
PMCPMC7809304
OpenAlexW3120365186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.