ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2021
Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: a systematic review and meta-analysis.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 6 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 6 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- The severity of dissociation and dissociative phenomena in non-affective psychosis: a systematic review and meta-analyses.BMC psychiatry · 2026Pooled it
- Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.Psychological medicine · 2025Pooled it
- Assessing dissociation: A systematic review and evaluation of existing measures.Journal of psychiatric research · 2025Pooled it
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- The effectiveness and tolerability of trauma-focused psychotherapies for psychotic symptoms: A systematic review of trauma-focused psychotherapies.International journal of methods in psychiatric research · 2024Pooled it
- Childhood trauma and hippocampal-dependent memory across the psychosis spectrum: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- The effect of trauma-focused therapy on voice-hearing: An experience sampling study.Psychology and psychotherapy · 2025Trial
- An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Do Psychological Interventions Reduce Paranoia in Adolescents? A Systematic Review.Clinical child and family psychology review · 2026Review
- The Effect of Developmental Trauma on Brain Structures Involved in Threat and Memory Processing and Its Relation to Psychotic Experiences in Adulthood.Schizophrenia bulletin · 2026Article
- Individual threat-relevance accelerates belief-updating in conditioned hallucinations.Scientific reports · 2026Article
- Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses.Psychological medicine · 2026Article
- Associations between PTSD and psychotic symptoms: A network analysis of patients with psychotic disorders in Uganda: Psychosis-PTSD network analysis.SSM. Mental health · 2026Article
- Disorganized attachment and identity dissociation: FKBP5 CATT as a molecular moderator.Psychiatry research · 2026Article
- Links between trauma and psychotic symptoms: Integrating cognitive behavioural and neuropsychoanalytic models of psychosis.Psychology and psychotherapy · 2026Review
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- Early Parenting and Infant-Parent Attachment: Developmental Origins of Psychotic Experiences.Brain and behavior · 2026Article
- Emotional processing deficits mediate the association between adverse childhood experiences and CPTSD symptoms: the moderating role of perceived social support.Frontiers in psychiatry · 2026Article
- Bidirectional relationships among complex PTSD, dissociation, and psychotic symptoms in two samples.European journal of psychotraumatology · 2025Article
- Dissociative experiences in individuals with subclinical psychosis and a history of developmental trauma: a qualitative study.European journal of psychotraumatology · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experiencing psychological trauma during childhood and/or adolescence is associated with an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how developmental trauma induces vulnerability to psychotic symptoms. Understanding the psychological processes involved in this association is crucial to the development of preventive interventions and improved treatments. We sought to systematically review the literature and combine findings using meta-analytic techniques to establish the potential roles of psychological processes in the associations between developmental trauma and specific psychotic experiences (i.e., hallucinations, delusions and paranoia). Twenty-two studies met our inclusion criteria. We found mediating roles of dissociation, emotional dysregulation and post-traumatic stress disorder (PTSD) symptoms (avoidance, numbing and hyperarousal) between developmental trauma and hallucinations. There was also evidence of a mediating role of negative schemata, i.e. mental constructs of meanings, between developmental trauma and delusions as well as paranoia. Many studies to date have been of poor quality, and the field is limited by mostly cross-sectional research. Our findings suggest that there may be distinct psy-chological pathways from developmental trauma to psychotic phenomena in adulthood. Clinicians should carefully ask people with psychosis about their history of developmental trauma, and screen patients with such a history for dissociation, emotional dysregulation and PTSD symptoms. Well conducted research with prospective designs, including neurocognitive assessment, is required in order to fully understand the biopsychosocial mechanisms underlying the association between developmental trauma and psychosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.