ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2021
Hierarchical models of psychopathology: empirical support, implications, and remaining issues.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- Interpersonal Distress as a Covariate of Mental Health in Depression: A Multilevel Meta-Analysis.Clinical psychology & psychotherapyPooled it
- Reproducible Temperament Profiles in Adolescents With Attention-Deficit/Hyperactivity Disorder Prospectively Predict Clinical Outcomes.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts.Journal of psychopathology and clinical science · 2026Article
- Beyond DSM Categories: Criteria for Biologically Valid Disease Axes in Psychiatry.Journal of clinical medicine · 2026Review
- Disentangling shared and unique effects of parenting on psychopathology: Evidence from two prospective, genetically sensitive cohort studies.JCPP advances · 2026Article
- Language or syndrome? Investigating the origins of the general psychopathology factor through large language model embeddings.Psychiatry and clinical neurosciences · 2026Article
- How are children's perceptions of the home environment associated with a general psychopathology factor across childhood?Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Human approach-avoidance conflict behaviour relates to transdiagnostic psychiatric symptom dimensions.Translational psychiatry · 2026Article
- Psychometric properties of hierarchical psychiatric symptoms on the general population.PLOS mental health · 2026Article
- Parental income and psychiatric disorders from age 10 to 40: a genetically informative population study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Understanding the Etiology of Externalizing Problems in Young Children: The Roles of Callous-Unemotional Traits and Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Association between the childhood rearing environment and general and specific psychopathology factors in middle adulthood: a Swedish National High-Risk Home-Reared versus Adopted-Away Sibling Comparison Study.Molecular psychiatry · 2025Observational
- Adolescent Sleep as a Transdiagnostic Factor: Associations Between Actigraphy-Derived Night-to-Night Sleep Metrics and Adolescent Psychopathology.JAACAP open · 2025Article
- Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission.Development and psychopathology · 2025Article
- Evaluation of sleep-wake disorders with the Kiddie Schedule for Affective Disorders and Schizophrenia for Children and Adolescents: Present and Lifetime version 5.1.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood.Nature communications · 2025Article
- Oscillatory components of bidirectional cardio-respiratory coupling in depression and suicidal ideation: insights from swarm decomposition and entropy analysis.Frontiers in network physiology · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
There is an ongoing revolution in psychology and psychiatry that will likely change how we conceptualize, study and treat psychological problems.- Many theorists now support viewing psychopathology as consisting of continuous dimensions rather than discrete diagnostic categories. Indeed, recent papers have proposed comprehensive taxonomies of psychopathology dimensions to replace the DSM and ICD taxonomies of categories. The proposed dimensional taxonomies, which portray psychopathology as hierarchically organized correlated dimensions, are now well supported at phenotypic levels. Multiple studies show that both a general factor of psychopathology at the top of the hierarchy and specific factors at lower levels predict different functional outcomes. Our analyses of data on a large representative sample of child and adolescent twins suggested the causal hypothesis that phenotypic correlations among dimensions of psychopathology are the result of many familial influences being pleiotropic. That is, most genetic variants and shared environmental factors are hypothesized to non-specifically influence risk for multiple rather than individual dimensions of psychopathology. In contrast, person-specific experiences tend to be related to individual dimensions. This hierarchical causal hypothesis has been supported by both large-scale family and molecular genetic studies. Current research focuses on three issues. First, the field has not settled on a preferred statistical model for studying the hierarchy of causes and phenotypes. Second, in spite of encouraging progress, the neurobiological correlates of the hierarchy of dimensions of psychopathology are only partially described. Third, although there are potentially important clinical implications of the hierarchical model, insufficient research has been conducted to date to rec-ommend evidence-based clinical practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.