Evidence map›Paper›PMID 33432656›Full record

ReviewJournal of child psychology and psychiatry, and allied disciplines2021

Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders.

Mark H Johnson, Tony Charman, Andrew Pickles, Emily J H Jones

Abstract readReview
In one paragraph

Review in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mark H JohnsonCentre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-1993-6549
Andrew PicklesDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Emily J H JonesCentre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, London, UK.

Funding

Medical Research Council MR/T003057/1
6 · The paper itself

Abstract

We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.

Indexed as

Neurodevelopmental DisordersNeurosciencesChildChild, PreschoolDevelopmental DisabilitiesHumansProspective StudiesPsychopathologyautism spectrum disordersbrain developmentNeurodevelopmental disorders

Identifiers

PMID33432656
PMCPMC8609429

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.