ArticleJournal of neurovirology2021
Low levels of frailty in HIV-positive older adults on antiretroviral therapy in northern Tanzania.
Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.BMJ open · 2021Pooled it
- Correlates of Poor Quality of Life Among Older People Living With HIV: A Cross-Sectional Analysis of the Tanzania HIV and Aging Cohort Study.Journal of the International AIDS Society · 2026Article
- Article
- Frailty among adult people living with HIV in Tanzania: a single-centred hospital-based cross-sectional study.BMJ public health · 2026Article
- Prevalence and factors associated with frailty among older adults with and without HIV in Kampala, Uganda.AIDS research and therapy · 2025Article
- Predictors of survival among older adults with HIV in Uganda's AIDS support organization centers of excellence (1987-2023): a retrospective longitudinal study.AIDS research and therapy · 2025Article
- Prevalence, factors and quality of life associated with frailty and pre-frailty in middle-aged and older adults living with HIV in Zimbabwe: A cross-sectional study.HIV medicine · 2025Article
- Global frailty screening tools: Review and application of frailty screening tools from 2001 to 2023.Intractable & rare diseases research · 2024Review
- Prevalence and Factors Associated With Frailty Among Older Adults Living With HIV Compared to Their Uninfected Peers From the Kenyan Coast.International journal of public health · 2024Article
- Sex Differences in the Prevalence of Geriatric Syndromes Among Older People Living with HIV Attending an Urban Outpatient Clinic in Kampala, Uganda.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Differences between persons with and without disability in HIV prevalence, testing, treatment, and care cascade in Tanzania: a cross-sectional study using population-based data.BMC public health · 2023Article
- Patient priority setting in HIV ageing research: exploring the feasibility of community engagement and involvement in Tanzania.Research involvement and engagement · 2023Article
- Article
- Providing differentiated service delivery to the ageing population of people living with HIV.Journal of the International AIDS Society · 2022Article
- Food insecurity and frailty among women with and without HIV in the United States: a cross-sectional analysis.Journal of the International AIDS Society · 2021Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are over 3 million people in sub-Saharan Africa (SSA) aged 50 and over living with HIV. HIV and combined antiretroviral therapy (cART) exposure may accelerate the ageing in this population, and thus increase the prevalence of premature frailty. There is a paucity of data on the prevalence of frailty in an older HIV + population in SSA and screening and diagnostic tools to identify frailty in SSA. Patients aged ≥ 50 were recruited from a free Government HIV clinic in Tanzania. Frailty assessments were completed, using 3 diagnostic and screening tools: the Fried frailty phenotype (FFP), Clinical Frailty Scale (CFS) and Brief Frailty Instrument for Tanzania (B-FIT 2). The 145 patients recruited had a mean CD4 + of 494.84 cells/µL, 99.3% were receiving cART and 72.6% were virally suppressed. The prevalence of frailty by FFP was 2.758%. FFP frailty was significantly associated with female gender (p = 0.006), marital status (p = 0.007) and age (p = 0.038). Weight loss was the most common FFP domain failure. The prevalence of frailty using the B-FIT 2 and the CFS was 0.68%. The B-FIT 2 correlated with BMI (r = - 0.467, p = 0.0001) and CD4 count in females (r = - 0.244, p = 0.02). There is an absence of frailty in this population, as compared to other clinical studies. This may be due to the high standard of HIV care at this Government clinic. Undernutrition may be an important contributor to frailty. It is unclear which tool is most accurate for detecting the prevalence of frailty in this setting as levels of correlation are low.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.